Improving the production of monensin by Streptomyces cinnamonensis

The production of monensin by Streptomyces cinnamonensis was increased by genetic improvement of the strain and by modification of cultivation conditions. The selection of a suitable strain and optimization of the fermentation process (temperature, aeration, addition of esters of oleic acid) resulte...

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Bibliographic Details
Published in:Folia microbiologica 1984, Vol.29 (1), p.35-42
Main Authors: KRALOVCOVA, E, KRUMPHANZL, V, VANEK, Z
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Antibiotics
Bacteriological Techniques
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Furans - biosynthesis
Gene Expression Regulation
genetic engineering
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
monensin
Monensin - biosynthesis
Production of active biomolecules
Streptococcus - metabolism
Streptomyces cinnamonensis
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Summary:The production of monensin by Streptomyces cinnamonensis was increased by genetic improvement of the strain and by modification of cultivation conditions. The selection of a suitable strain and optimization of the fermentation process (temperature, aeration, addition of esters of oleic acid) resulted in a 30 fold increase of the monensin production.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02875906