Studies on Curcumin and Curcuminoids IX: Investigation of the Photobiological Activity of Curcumin Using Bacterial Indicator Systems

The dye curcumin is a natural, nontoxic food constituent. On irradiation with visible light, curcumin proves to be phototoxic for Salmonella typhimurium and Escherichia coli, even at very low concentrations. The observed phototoxicity makes curcumin a potential photosensitizing drug which might find...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1987-05, Vol.76 (5), p.371-373
Main Authors: Tønnesen, Hanne Hjorth, de Vries, Henk, Karlsen, Jan, Van Henegouwen, Gerard Beijersbergen
Format: Article
Language:English
Subjects:
Biological and medical sciences
Catechols - pharmacology
Curcumin - pharmacology
Curcumin - radiation effects
Curcumin - therapeutic use
DNA, Bacterial - drug effects
Drug toxicity and drugs side effects treatment
Escherichia coli - drug effects
Escherichia coli - genetics
Hydrogen-Ion Concentration
Hydrolysis
Light
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Photochemotherapy
Salmonella typhimurium - drug effects
Salmonella typhimurium - genetics
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Summary:The dye curcumin is a natural, nontoxic food constituent. On irradiation with visible light, curcumin proves to be phototoxic for Salmonella typhimurium and Escherichia coli, even at very low concentrations. The observed phototoxicity makes curcumin a potential photosensitizing drug which might find application in the phototherapy of, for example, psoriasis, cancer, and bacterial and viral diseases.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600760506