Familial inv(1) (p3500q21.3) associated with azoospermia

An inv(1) (p3500q21.3) was found in an azoospermic man, his mother and two other maternal relatives. Although the mechanisms involved are still unclear, it is stressed that pericentric inversions of chromosome 1 in which the inverted chromosome becomes submetacentric (centromeric index less than or...

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Bibliographic Details
Published in:Human genetics 1984-01, Vol.66 (2-3), p.165-167
Main Authors: Rivera, H, Alvarez-Arratia, M C, Moller, M, Díaz, M, Cantú, J M
Format: Article
Language:English
Subjects:
Adult
Chromosome Banding
Chromosome Inversion
Chromosomes, Human, 1-3
Female
Humans
Karyotyping
Male
Oligospermia - genetics
Oligospermia - pathology
Pedigree
Testis - pathology
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Summary:An inv(1) (p3500q21.3) was found in an azoospermic man, his mother and two other maternal relatives. Although the mechanisms involved are still unclear, it is stressed that pericentric inversions of chromosome 1 in which the inverted chromosome becomes submetacentric (centromeric index less than or equal to 0.324) apparently impair spermatogenesis.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00286593