Effects of endotoxin (lipopolysaccharides) on experimental aspergillosis in leukemic mice

In an attempt to evaluate effects of bacterial endotoxin on systemic fungal infection, experimental systemic Aspergillus infection was induced in leukemic mice (AKR strain) with (Group B) or without (Group A) preceding intraperitoneal administration of Pseudomonas aeruginosa derived lipopolysacchari...

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Bibliographic Details
Published in:Mycopathologia (1975) 1987-08, Vol.99 (2), p.95-97
Main Authors: ABE, F, KATOH, T, KANEKO, T, HOTCHI, M
Format: Article
Language:English
Subjects:
Animals
Aspergillosis - therapy
Aspergillus fumigatus
Biological and medical sciences
Endotoxins - therapeutic use
Experimental mycoses and models
Immunotherapy
Infectious diseases
Leukemia, Experimental - complications
Leukemia, Experimental - therapy
Lipopolysaccharides - therapeutic use
Medical sciences
Mice
Mice, Inbred AKR
Mycoses
Pseudomonas aeruginosa
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Summary:In an attempt to evaluate effects of bacterial endotoxin on systemic fungal infection, experimental systemic Aspergillus infection was induced in leukemic mice (AKR strain) with (Group B) or without (Group A) preceding intraperitoneal administration of Pseudomonas aeruginosa derived lipopolysaccharides. All mice in group A died within 4 days after intravenous inoculation of Aspergillus fumigatus spores and developed extensive and disseminated fungal lesions without inflammatory reactions. In contrast, 5 of 10 mice in group B were alive at day 4 and 1 mouse in group B was alive when the experiment was terminated on the 14th day. These mice showed less extensive fungal lesions with definite, albeit minimal, inflammatory reactions which were composed of macrophages and neutrophils. In addition, serum iron levels and iron saturation rates were significantly lower in mice in group B than in group A. These results indicate that P. aeruginosa endotoxin has a deterring effect on systemic Aspergillus infection in leukemic mice.
ISSN:0301-486X
1573-0832
DOI:10.1007/BF00436912