Multiple and Persistent Viral Infections in a Patient With Bare Lymphocyte Syndrome

Bare lymphocyte syndrome (BLS), first described by Schuurman et al. and Touraine et al., is characterized by the lack of expression of class I and/or II HLA antigens and beta -microglobulin on lymphocytes, an occurrence resulting in a form of partial combined immunodeficiency (CID). Clinical manifes...

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Bibliographic Details
Published in:The Journal of infectious diseases 1987-11, Vol.156 (5), p.837-840
Main Authors: Arens, Max Q., Knutsen, Alan P., Schwarz, Kathleen B., Roodman, Stanford T., Swierkosz, Ella M.
Format: Article
Language:English
Subjects:
Adenoviridae Infections - complications
Adenovirus Infections, Human - complications
Adenoviruses
Antigens, Surface - analysis
B lymphocytes
Biological and medical sciences
Blood
Concise Communications
Enterovirus
Enterovirus Infections - complications
HLA antigens
HLA Antigens - analysis
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulins - analysis
Immunologic Deficiency Syndromes - complications
Immunologic Deficiency Syndromes - immunology
Immunopathology
Infant
Lymphocyte Culture Test, Mixed
Lymphocytes
Lymphocytes - immunology
Male
Medical sciences
Picornaviridae Infections - complications
Rhinovirus
Syndrome
T lymphocytes
Viral infections
Viruses
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Summary:Bare lymphocyte syndrome (BLS), first described by Schuurman et al. and Touraine et al., is characterized by the lack of expression of class I and/or II HLA antigens and beta -microglobulin on lymphocytes, an occurrence resulting in a form of partial combined immunodeficiency (CID). Clinical manifestations have included oral candidiasis, Pneumocystis carinii and bacterial pneumonias, diarrhea resulting in growth failure, septicemia, and viral infections. In this report, the authors describe the clinical diagnosis and hospital course of a Caucasian infant of Irish and English descent with BLS who had multiple and simultaneous viral infections. He was treated with high-dose, intravenous gammaglobulin (IVIG) in attempts to contain infections with multiple enteroviruses, rhinovirus, and two serotypes of adenovirus.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/156.5.837