Complete sequence of the heat shock-inducible HSP90 gene of Saccharomyces cerevisiae

We have sequenced the yeast HSP90 gene, which encodes the (apparent) Mr = 90,000 heat shock-inducible protein of this organism. All sequences required for the heat shock-regulated expression of this gene reside on a segment of DNA containing no more than 273 nucleotides 5' to the transcription...

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Bibliographic Details
Published in:The Journal of biological chemistry 1984-05, Vol.259 (9), p.5745-5751
Main Authors: Farrelly, F W, Finkelstein, D B
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Biological and medical sciences
Codon
DNA Restriction Enzymes
Fundamental and applied biological sciences. Psychology
Genes
Genes, Fungal
Genes. Genome
Heat-Shock Proteins - biosynthesis
Heat-Shock Proteins - genetics
Molecular and cellular biology
Molecular genetics
RNA, Messenger - genetics
Saccharomyces cerevisiae - genetics
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Summary:We have sequenced the yeast HSP90 gene, which encodes the (apparent) Mr = 90,000 heat shock-inducible protein of this organism. All sequences required for the heat shock-regulated expression of this gene reside on a segment of DNA containing no more than 273 nucleotides 5' to the transcription origin. Transcript mapping reveals that the mature hsp90 mRNA contains a 59-nucleotide 5' untranslated segment, a coding segment of 2130 nucleotides (sufficient to encode a protein of Mr = 81,419), and a 3' untranslated segment of 128 nucleotides. Although the sequences surrounding the coding region of the HSP90 gene are quite similar to those surrounding other sequenced yeast genes, we find as well a limited homology between sequences located 5' to this gene and the putative heat shock-regulatory sequences located 5' to the heat shock-inducible genes of Drosophila.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)91077-X