Auxotype/Serovar Diversity and Antimicrobial Resistance of Neisseria gonorrhoeae in Two Mid-Sized American Cities

To characterize the prevalence and heterogeneity of Neisseria gonorrhoeae with chromosomally mediated resistance to penicillin G or tetracycline. HC1 in Seattle, Washington, and Denver, Colorado, we auxotyped, serotyped, and determined the MICs of penicillin G and tetracycline for gonococcal isolate...

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Published in:Sexually transmitted diseases 1987-07, Vol.14 (3), p.141-146
Main Authors: HOOK, EDWARD W., JUDSON, FRANKLYN N., HANDSFIELD, H. HUNTER, EHRET, JOSEPHINE M., HOLMES, KING K., KNAPP, JOAN S.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Colorado
Female
Humans
Male
Medical sciences
Microbial Sensitivity Tests
Neisseria gonorrhoeae - classification
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
Original Articles
Penicillin G - pharmacology
Penicillin Resistance - genetics
Pharmacology. Drug treatments
Tetracycline - pharmacology
Tetracycline Resistance - genetics
Washington
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Summary:To characterize the prevalence and heterogeneity of Neisseria gonorrhoeae with chromosomally mediated resistance to penicillin G or tetracycline. HC1 in Seattle, Washington, and Denver, Colorado, we auxotyped, serotyped, and determined the MICs of penicillin G and tetracycline for gonococcal isolates collected in both cities during 1984. In Seattle 37 (18%) and ten (5%) of 205 isolates had MICs for penicillin G of ⩾1.0 and ⩾2.0 μg/ml, respectively; in Denver eight (3%) of 240 isolates had MICs for penicillin of 1.0 μg/ml, and none had MICs of > 1.0 μg/ml. For tetracycline · HCI, 107 (52%) and 38 (19%) of Seattle isolates had MICs of ⩾1.0 and ⩾2.0 μg/ml, respectively, while in Denver the respective figures were 111 (46%) and 48 (20%). In each city, antimicrobial resistance was present in a number of auxotype/serovar (A/S) classes: isolates with MICs for penicillin G of ⩾1.0 Mg/ml were identified in 15 of 49 A/S classes in Seattle and in five of 49 A/S classes in Denver. These data indicate that chromosomal resistance to penicillin G and tetracycline · HCI varies geographically in prevalence and is a heterogeneous phenomenon involving multiple gonococcal strains.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-198707000-00004