The Influence of Androgens on Paralysis in Mice Following Intravenous Inoculation of Herpes Simplex Virus

Department of Microbiology, Medical School, University Walk, Bristol BS8 1TD, U.K. In mice, intravenous inoculation of relatively avirulent strains of herpes simplex virus [e.g. P 2 C 6 , a mutant of strain CL(101), deficient in thymidine kinase] produced infection in the adrenal gland and mid-spina...

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Bibliographic Details
Published in:Journal of general virology 1987-09, Vol.68 (9), p.2461-2464
Main Authors: Yirrell, D. L, Blyth, W. A, Hill, T. J
Format: Article
Language:English
Subjects:
Adrenal Glands - microbiology
Animals
Biological and medical sciences
Disease Susceptibility
Experimental viral diseases and models
Female
Herpes Simplex - physiopathology
herpes simplex virus
Infectious diseases
Male
Medical sciences
Mice
Mice, Inbred Strains
Orchiectomy
Paralysis - microbiology
Paralysis - physiopathology
Sex Factors
Simplexvirus - pathogenicity
Species Specificity
Spinal Cord - microbiology
Testosterone - pharmacology
Viral diseases
Virulence
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Summary:Department of Microbiology, Medical School, University Walk, Bristol BS8 1TD, U.K. In mice, intravenous inoculation of relatively avirulent strains of herpes simplex virus [e.g. P 2 C 6 , a mutant of strain CL(101), deficient in thymidine kinase] produced infection in the adrenal gland and mid-spinal cord followed by hind limb paralysis without death. Male mice were less susceptible to paralysis than female mice. Castration of male mice before inoculation increased their susceptibility to that of female animals; treatment with testosterone reversed this change. The differences in susceptibility to paralysis in the various categories of animal were not reflected in differences in growth of virus in the adrenal gland or spinal cord. Keywords: HSV-1, paralysis, androgens Received 27 February 1987; accepted 27 May 1987.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-68-9-2461