Crystal-matrix relationships in experimentally induced urinary calcium oxalate monohydrate crystals, and ultrastructural study

Calcium oxalate monohydrate crystalluria was experimentally induced in male rats by administration of ethylene glycol. The crystalluria particles were separated by filtration and studied by scanning and transmission electron microscopy. They were associated with cellular degradation products. Organi...

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Bibliographic Details
Published in:Calcified tissue international 1987-09, Vol.41 (3), p.157-163
Main Authors: KHAN, S. R, HACKETT, R. L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium Oxalate - urine
Ethylene Glycols
Male
Medical sciences
Microscopy, Electron
Nephrology. Urinary tract diseases
Rats
Rats, Inbred Strains
Urinary Bladder Calculi - analysis
Urinary Bladder Calculi - ultrastructure
Urinary lithiasis
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Summary:Calcium oxalate monohydrate crystalluria was experimentally induced in male rats by administration of ethylene glycol. The crystalluria particles were separated by filtration and studied by scanning and transmission electron microscopy. They were associated with cellular degradation products. Organic material was present both on the surfaces of crystalluria particles as well as within them and was organized in radial striations and concentric laminations. It is proposed that crystal nuclei were formed by heterogeneous nucleation. These nuclei then adsorbed organic material and aggregated. The organic material polymerized resulting in the formation of a crystal-matrix unit which then grew and incorporated more organic material during the crystal growth.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02563796