The effect of cardioplegic oxygenation on the correlation between the linearized Frank-Starling relationship and myocardial energetics in the ejecting postischemic heart

To ascertain whether oxygenated cardioplegia is beneficial during surgically induced global ischemia, 27 canine hearts underwent sonomicrometric determination of cardiac mechanics and energetics during volume loading on right heart bypass before and after 2 hr of potassium cardioplegic arrest with c...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1987-11, Vol.76 (5 Pt 2), p.V122-V128
Main Authors: Krukenkamp, I B, Silverman, N A, Levitsky, S
Format: Article
Language:English
Subjects:
Animals
Cardiac Output
Cardioplegic Solutions
Coronary Circulation
Dogs
Heart - physiology
Heart Arrest, Induced
Hypothermia, Induced
Myocardium - metabolism
Oxygen
Oxygen Consumption
Potassium
Potassium Compounds
Space life sciences
Stroke Volume
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Summary:To ascertain whether oxygenated cardioplegia is beneficial during surgically induced global ischemia, 27 canine hearts underwent sonomicrometric determination of cardiac mechanics and energetics during volume loading on right heart bypass before and after 2 hr of potassium cardioplegic arrest with crystalloid, oxygenated crystalloid, or blood vehicles. The slope of the linear stroke work vs end-diastolic volume relationship, an index of contractility, was preserved by each vehicle. Similarly, oxygen utilization to perform external mechanical work during reperfusion was unaffected in all groups. However, there were significant 119% and 122% increases in basal oxygen utilization after both unoxygenated and oxygenated crystalloid cardioplegia (p less than .05) that were prevented by the blood-based vehicle. These data suggest that the salutary effects of blood cardioplegia on postischemic myocardial energetics may not be solely mediated by its oxygen-carrying capacity.
ISSN:0009-7322