Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended hapl...

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Bibliographic Details
Published in:Arthritis and rheumatism 1984-05, Vol.27 (5), p.516-521
Main Authors: Raum, D., Awdeh, Z., Glass, D., Kammer, G., Khan, M. A., Coblyn, J. S., Weinblatt, M., Holdsworth, D., Strong, L., Rossen, R. D., Brewer, E., Yunis, E., Alper, C. A.
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Alleles
Arthritis, Rheumatoid - genetics
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, 6-12 and X
Complement System Proteins - genetics
Diseases of the osteoarticular system
European Continental Ancestry Group
Gene Frequency
Haploidy
HLA Antigens - genetics
HLA-B Antigens
Humans
Inflammatory joint diseases
Major Histocompatibility Complex
Medical sciences
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Summary:In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780270506