Loading…

Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended hapl...

Full description

Saved in:

Bibliographic Details
Published in:	Arthritis and rheumatism 1984-05, Vol.27 (5), p.516-521
Main Authors:	Raum, D., Awdeh, Z., Glass, D., Kammer, G., Khan, M. A., Coblyn, J. S., Weinblatt, M., Holdsworth, D., Strong, L., Rossen, R. D., Brewer, E., Yunis, E., Alper, C. A.
Format:	Article
Language:	English
Subjects:	Adult African Continental Ancestry Group Alleles Arthritis, Rheumatoid - genetics Biological and medical sciences Chromosome Mapping Chromosomes, Human, 6-12 and X Complement System Proteins - genetics Diseases of the osteoarticular system European Continental Ancestry Group Gene Frequency Haploidy HLA Antigens - genetics HLA-B Antigens Humans Inflammatory joint diseases Major Histocompatibility Complex Medical sciences
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293
cites	cdi_FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293
container_end_page	521
container_issue	5
container_start_page	516
container_title	Arthritis and rheumatism
container_volume	27
creator	Raum, D. Awdeh, Z. Glass, D. Kammer, G. Khan, M. A. Coblyn, J. S. Weinblatt, M. Holdsworth, D. Strong, L. Rossen, R. D. Brewer, E. Yunis, E. Alper, C. A.
description	In 46 patients with rheumatoid arthritis (RA) the allele C4B3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B3: HLA—‐B15, DR4, BFS, C2C, C4A3, C4B3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.
doi_str_mv	10.1002/art.1780270506
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81061584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>13921064</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293</originalsourceid><addsrcrecordid>eNqFkM1Lw0AQxRdRaq1evQk5iLfUnSS72T2WUj-gIEg9h-nuhkSSbNxN0P73pjRUbz0Nw_vNvJlHyC3QOVAaPaLr5pAKGqWUUX5GpsAiGVKI4ZxMKaVJGDMJl-TK-8-hjWIWT8iEM8FBwJQsVj-dabTRQYFtZbtda3xg80AVztbW29oEPCibAHVfdYErTF9jZ0sdDL6FK7vSX5OLHCtvbsY6Ix9Pq83yJVy_Pb8uF-tQJQnlIVAmkQujUKuIU9yCQclik2yHu3OdGJkyhZCj1jlPGct5QlMUiinAVEYynpGHw97W2a_e-C6rS69MVWFjbO8zAZQDE8lJEGIZDewenB9A5az3zuRZ68oa3S4Dmu3DzYYns79wh4G7cXO_rY0-4mOag34_6ugVVrnDRpX-iEku0jQSAyYP2HdZmd0J02zxvvl3wi962JJN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13921064</pqid></control><display><type>article</type><title>Extended haplotypes of chromosome 6 in adult rheumatoid arthritis</title><source>Alma/SFX Local Collection</source><creator>Raum, D. ; Awdeh, Z. ; Glass, D. ; Kammer, G. ; Khan, M. A. ; Coblyn, J. S. ; Weinblatt, M. ; Holdsworth, D. ; Strong, L. ; Rossen, R. D. ; Brewer, E. ; Yunis, E. ; Alper, C. A.</creator><creatorcontrib>Raum, D. ; Awdeh, Z. ; Glass, D. ; Kammer, G. ; Khan, M. A. ; Coblyn, J. S. ; Weinblatt, M. ; Holdsworth, D. ; Strong, L. ; Rossen, R. D. ; Brewer, E. ; Yunis, E. ; Alper, C. A.</creatorcontrib><description>In 46 patients with rheumatoid arthritis (RA) the allele C4B3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B3: HLA—‐B15, DR4, BFS, C2C, C4A3, C4B3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780270506</identifier><identifier>PMID: 6586181</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; African Continental Ancestry Group ; Alleles ; Arthritis, Rheumatoid - genetics ; Biological and medical sciences ; Chromosome Mapping ; Chromosomes, Human, 6-12 and X ; Complement System Proteins - genetics ; Diseases of the osteoarticular system ; European Continental Ancestry Group ; Gene Frequency ; Haploidy ; HLA Antigens - genetics ; HLA-B Antigens ; Humans ; Inflammatory joint diseases ; Major Histocompatibility Complex ; Medical sciences</subject><ispartof>Arthritis and rheumatism, 1984-05, Vol.27 (5), p.516-521</ispartof><rights>Copyright © 1984 American College of Rheumatology</rights><rights>1984 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293</citedby><cites>FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9687728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6586181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raum, D.</creatorcontrib><creatorcontrib>Awdeh, Z.</creatorcontrib><creatorcontrib>Glass, D.</creatorcontrib><creatorcontrib>Kammer, G.</creatorcontrib><creatorcontrib>Khan, M. A.</creatorcontrib><creatorcontrib>Coblyn, J. S.</creatorcontrib><creatorcontrib>Weinblatt, M.</creatorcontrib><creatorcontrib>Holdsworth, D.</creatorcontrib><creatorcontrib>Strong, L.</creatorcontrib><creatorcontrib>Rossen, R. D.</creatorcontrib><creatorcontrib>Brewer, E.</creatorcontrib><creatorcontrib>Yunis, E.</creatorcontrib><creatorcontrib>Alper, C. A.</creatorcontrib><title>Extended haplotypes of chromosome 6 in adult rheumatoid arthritis</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>In 46 patients with rheumatoid arthritis (RA) the allele C4B3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B3: HLA—‐B15, DR4, BFS, C2C, C4A3, C4B3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.</description><subject>Adult</subject><subject>African Continental Ancestry Group</subject><subject>Alleles</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, 6-12 and X</subject><subject>Complement System Proteins - genetics</subject><subject>Diseases of the osteoarticular system</subject><subject>European Continental Ancestry Group</subject><subject>Gene Frequency</subject><subject>Haploidy</subject><subject>HLA Antigens - genetics</subject><subject>HLA-B Antigens</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Major Histocompatibility Complex</subject><subject>Medical sciences</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNqFkM1Lw0AQxRdRaq1evQk5iLfUnSS72T2WUj-gIEg9h-nuhkSSbNxN0P73pjRUbz0Nw_vNvJlHyC3QOVAaPaLr5pAKGqWUUX5GpsAiGVKI4ZxMKaVJGDMJl-TK-8-hjWIWT8iEM8FBwJQsVj-dabTRQYFtZbtda3xg80AVztbW29oEPCibAHVfdYErTF9jZ0sdDL6FK7vSX5OLHCtvbsY6Ix9Pq83yJVy_Pb8uF-tQJQnlIVAmkQujUKuIU9yCQclik2yHu3OdGJkyhZCj1jlPGct5QlMUiinAVEYynpGHw97W2a_e-C6rS69MVWFjbO8zAZQDE8lJEGIZDewenB9A5az3zuRZ68oa3S4Dmu3DzYYns79wh4G7cXO_rY0-4mOag34_6ugVVrnDRpX-iEku0jQSAyYP2HdZmd0J02zxvvl3wi962JJN</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>Raum, D.</creator><creator>Awdeh, Z.</creator><creator>Glass, D.</creator><creator>Kammer, G.</creator><creator>Khan, M. A.</creator><creator>Coblyn, J. S.</creator><creator>Weinblatt, M.</creator><creator>Holdsworth, D.</creator><creator>Strong, L.</creator><creator>Rossen, R. D.</creator><creator>Brewer, E.</creator><creator>Yunis, E.</creator><creator>Alper, C. A.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Extended haplotypes of chromosome 6 in adult rheumatoid arthritis</title><author>Raum, D. ; Awdeh, Z. ; Glass, D. ; Kammer, G. ; Khan, M. A. ; Coblyn, J. S. ; Weinblatt, M. ; Holdsworth, D. ; Strong, L. ; Rossen, R. D. ; Brewer, E. ; Yunis, E. ; Alper, C. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>African Continental Ancestry Group</topic><topic>Alleles</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, 6-12 and X</topic><topic>Complement System Proteins - genetics</topic><topic>Diseases of the osteoarticular system</topic><topic>European Continental Ancestry Group</topic><topic>Gene Frequency</topic><topic>Haploidy</topic><topic>HLA Antigens - genetics</topic><topic>HLA-B Antigens</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Major Histocompatibility Complex</topic><topic>Medical sciences</topic><toplevel>online_resources</toplevel><creatorcontrib>Raum, D.</creatorcontrib><creatorcontrib>Awdeh, Z.</creatorcontrib><creatorcontrib>Glass, D.</creatorcontrib><creatorcontrib>Kammer, G.</creatorcontrib><creatorcontrib>Khan, M. A.</creatorcontrib><creatorcontrib>Coblyn, J. S.</creatorcontrib><creatorcontrib>Weinblatt, M.</creatorcontrib><creatorcontrib>Holdsworth, D.</creatorcontrib><creatorcontrib>Strong, L.</creatorcontrib><creatorcontrib>Rossen, R. D.</creatorcontrib><creatorcontrib>Brewer, E.</creatorcontrib><creatorcontrib>Yunis, E.</creatorcontrib><creatorcontrib>Alper, C. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raum, D.</au><au>Awdeh, Z.</au><au>Glass, D.</au><au>Kammer, G.</au><au>Khan, M. A.</au><au>Coblyn, J. S.</au><au>Weinblatt, M.</au><au>Holdsworth, D.</au><au>Strong, L.</au><au>Rossen, R. D.</au><au>Brewer, E.</au><au>Yunis, E.</au><au>Alper, C. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extended haplotypes of chromosome 6 in adult rheumatoid arthritis</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1984-05</date><risdate>1984</risdate><volume>27</volume><issue>5</issue><spage>516</spage><epage>521</epage><pages>516-521</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>In 46 patients with rheumatoid arthritis (RA) the allele C4B3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B3: HLA—‐B15, DR4, BFS, C2C, C4A3, C4B3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>6586181</pmid><doi>10.1002/art.1780270506</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0004-3591
ispartof	Arthritis and rheumatism, 1984-05, Vol.27 (5), p.516-521
issn	0004-3591 1529-0131
language	eng
recordid	cdi_proquest_miscellaneous_81061584
source	Alma/SFX Local Collection
subjects	Adult African Continental Ancestry Group Alleles Arthritis, Rheumatoid - genetics Biological and medical sciences Chromosome Mapping Chromosomes, Human, 6-12 and X Complement System Proteins - genetics Diseases of the osteoarticular system European Continental Ancestry Group Gene Frequency Haploidy HLA Antigens - genetics HLA-B Antigens Humans Inflammatory joint diseases Major Histocompatibility Complex Medical sciences
title	Extended haplotypes of chromosome 6 in adult rheumatoid arthritis
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T08%3A47%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extended%20haplotypes%20of%20chromosome%206%20in%20adult%20rheumatoid%20arthritis&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Raum,%20D.&rft.date=1984-05&rft.volume=27&rft.issue=5&rft.spage=516&rft.epage=521&rft.pages=516-521&rft.issn=0004-3591&rft.eissn=1529-0131&rft.coden=ARHEAW&rft_id=info:doi/10.1002/art.1780270506&rft_dat=%3Cproquest_cross%3E13921064%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4406-1059a68ecadc260ab1ea953e4b050fd4e975ca1faddf6755f6407a8c5c1a79293%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=13921064&rft_id=info:pmid/6586181&rfr_iscdi=true