Thyroid‐associated antigens in routinely embedded carcinomas. Possibilities and limitations studied in 116 cases

Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid‐associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and p...

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Bibliographic Details
Published in:Cancer 1984-07, Vol.54 (2), p.274-279
Main Authors: Logmans, Sonja C., Jöbsis, Adriaan C.
Format: Article
Language:English
Subjects:
Adenocarcinoma - immunology
Adult
Antigens, Neoplasm - analysis
Biological and medical sciences
Calcitonin - analysis
Carcinoembryonic Antigen - analysis
Carcinoma - analysis
Carcinoma, Papillary - immunology
Endocrinopathies
Female
Histocytochemistry
Humans
Immunochemistry
Male
Malignant tumors
Medical sciences
Middle Aged
Neoplasm Metastasis - immunology
Retrospective Studies
Staining and Labeling
Thyroglobulin - analysis
Thyroid Neoplasms - immunology
Thyroid. Thyroid axis (diseases)
Citations: Items that this one cites
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Summary:Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid‐associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas stained positive for thyroglobulin; 14 of the 23 undifferentiated carcinomas showed only a focal and weak reaction for thyroglobulin. The metastases showed the same reaction pattern as the primary lesion. Calcitonin was present only in the medullary carcinomas and in 2 of the 23 undifferentiated carcinomas. Carcinoembryonic antigen was not present frequently in the investigated carcinomas. The reliability of the method, its clinical importance, and the possibilities it offers for a more precise classification are discussed. The diagnostic value of the method is illustrated by two case reports.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19840715)54:2<274::AID-CNCR2820540215>3.0.CO;2-1