Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer

Amplification of c-erbB-2 was at least three times more frequent in breast cancer than in most other types of carcinoma, and was not found in sarcomas or hematological malignancies. Amplification of c-erbB-2 was found in 15 of 86 primary breast cancers and in 3 of 12 secondary breast cancers. Amplif...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1987-11, Vol.47 (22), p.6123-6125
Main Authors: DUJIN ZHOU, BATTIFORA, H, YOKOTA, J, YAMAMOTO, T, CLINE, M. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Female
Gene Amplification
Gene Frequency
Gynecology. Andrology. Obstetrics
Humans
Lymphatic Metastasis
Mammary gland diseases
Medical sciences
Neoplasm Metastasis
Neoplasms - genetics
Neoplasms - pathology
Prognosis
Proto-Oncogenes
Tumors
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Summary:Amplification of c-erbB-2 was at least three times more frequent in breast cancer than in most other types of carcinoma, and was not found in sarcomas or hematological malignancies. Amplification of c-erbB-2 was found in 15 of 86 primary breast cancers and in 3 of 12 secondary breast cancers. Amplification was more common in breast tumors of advanced stage, and in tumors which had metastasized to regional lymph nodes sites. Gene amplification was observed in 21% (4 of 19) of primary tumors which recurred within 3 years of mastectomy and in 6% (2 of 32) of nonrecurrent tumors.
ISSN:0008-5472
1538-7445