Acute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapy

Flow cytometry (FCM) for the determination of DNA content and cell cycle analysis was performed on multiple bone marrows from a case of acute megakaryocytic leukemia in a 71‐year‐old woman. Two aneuploid (multiploid) peaks were present at diagnosis. This multiploidy was a stable characteristic when...

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Bibliographic Details
Published in:Cancer 1987-11, Vol.60 (10), p.2443-2447
Main Authors: Pantazis, Cooley G., Allsbrook, William C., Ades, Edwin, Houston, James, Brubaker, Leonard H.
Format: Article
Language:English
Subjects:
Aged
Anemia, Refractory, with Excess of Blasts - diagnosis
Aneuploidy
Biological and medical sciences
Carcinoma, Transitional Cell
Cell Cycle
DNA - analysis
Female
Flow Cytometry
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Thrombocythemia, Essential - diagnosis
Thrombocythemia, Essential - therapy
Urinary Bladder Neoplasms
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Summary:Flow cytometry (FCM) for the determination of DNA content and cell cycle analysis was performed on multiple bone marrows from a case of acute megakaryocytic leukemia in a 71‐year‐old woman. Two aneuploid (multiploid) peaks were present at diagnosis. This multiploidy was a stable characteristic when studied temporally. The disappearance of the peaks in the bone marrow specimens directly correlated with complete remission morphologically. These findings further support the concept of FCM as an adjunct to morphologic study in identifying residual tumor burden.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19871115)60:10<2443::AID-CNCR2820601016>3.0.CO;2-S