Prognostic and treatment factors affecting pelvic control of stage ib and iia‐b carcinoma of the intact uterine cervix treated with radiation therapy alone

• Published in: Cancer 1984-06, Vol.53 (12), p.2649-2654
• Main Authors: Mendenhall, William M., Thar, Timothy L., Bova, Francis J., Marcus, Robert B., Million, Rodney R., Morgan, Linda S.
• Format: Article
• Language: English
• Subjects: Actuarial Analysis; Adenocarcinoma - blood; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - radiotherapy; Adult; Age Factors; Biological and medical sciences; Brachytherapy; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Female; Follow-Up Studies; Gynecology. Andrology. Obstetrics; Hematocrit; Humans; Mammary gland diseases; Medical sciences; Middle Aged; Pelvic Neoplasms - secondary; Prognosis; Tumors; Uterine Cervical Neoplasms - blood; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(19840615)53:12<2649::AID-CNCR2820531213>3.0.CO;2-R

This is a retrospective analysis of 264 patients with Stage IB and IIA‐B carcinoma of the cervix treated with curative intent at the University of Florida from October 1964 through April 1980. There is a minimum 2‐year follow‐up. Patients dead of distant metastases (13), dead from intercurrent disease (14), or lost to follow‐up (1) less than 24 months from treatment with pelvic disease controlled were excluded from analysis of pelvic control. All patients were included in analysis of complications and survival. Tumor size and hematocrit were noted to be significant prognostic factors with regard to control of disease in the pelvis in Stage IB and IIA cancers. Tumor size and hematocrit also influenced pelvic control in Stage IIB, but to a lesser extent than in Stages IB and IIA. Patient age was a weak prognostic factor for control of disease in the pelvis for Stages IB, IIA, and IIB, but more strongly influenced pelvic control when considered in conjunction with tumor size and hematocrit. Overall treatment time influenced pelvic control in all cases when the size of the lesion was ≧6 cm. in lesions ≧6 cm in diameter, the amount of tumor regression noted at the time of the radium application after 3500 to 4000 rad external beam irradiation was a predictor of pelvic control. Data on treatment complications and survival are included, and future treatment strategies discussed.