The Effect of Gold Sodium Thiomalate in Adult Swiss/A2G Mice Infected with Togaviruses and Flaviviruses

Neurovirology Unit, Rayne Institute, St. Thomas' Hospital, The United Medical and Dental Schools of Guy's and St. Thomas' Hospitals, Lambeth Palace Road, London SE1 7EH, U.K. Treatment of adult mice with gold sodium thiomalate made the normally non-lethal Semliki Forest virus and Sind...

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Bibliographic Details
Published in:Journal of general virology 1987-10, Vol.68 (10), p.2665-2668
Main Authors: Mehta, S, Webb, H. E
Format: Article
Language:English
Subjects:
Action of physical and chemical agents
Animals
Antibody Formation
Biological and medical sciences
Brain - microbiology
Flavivirus - growth & development
Flavivirus - immunology
Fundamental and applied biological sciences. Psychology
Gold Sodium Thiomalate - pharmacology
Macrophages - microbiology
Membranes - physiopathology
Mice
Microbiology
Togaviridae - growth & development
Togaviridae - immunology
Togaviridae Infections - immunology
Togaviridae Infections - microbiology
Togaviridae Infections - physiopathology
Virology
Virus Replication
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Summary:Neurovirology Unit, Rayne Institute, St. Thomas' Hospital, The United Medical and Dental Schools of Guy's and St. Thomas' Hospitals, Lambeth Palace Road, London SE1 7EH, U.K. Treatment of adult mice with gold sodium thiomalate made the normally non-lethal Semliki Forest virus and Sindbis virus infections lethal and increased the virulence of Langat and West Nile viruses. These changes were associated with an enhanced virus invasion of the brain. Depression of the humoral antibody response was not observed. Keywords: togaviruses, flaviviruses, gold sodium thiomalate Received 11 June 1987; accepted 22 June 1987.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-68-10-2665