Excretion of ecdysteroids by schistosomes as a marker of parasite infection

Ecdysteroids produced by schistosomes are released in biological fluids of infected hosts. In the sera, the concentration of ecdysteroids correlates with the perimissiveness of the host to schistosome infection and its detection is available in the absence of positive parasitological tests. In the u...

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Bibliographic Details
Published in:FEBS letters 1984-03, Vol.168 (2), p.235-240
Main Authors: Nirde, P., De Reggi, M.L., Tsoupras, G., Torpier, G., Fressancourt, P., Capron, A.
Format: Article
Language:English
Subjects:
Adolescent
Animals
Biological and medical sciences
Body fluids
Child
Cricetinae
disease diagnosis
Diseases caused by trematodes
Ecdysteroids
Ecdysterone
Ecdysterone - urine
Experimental helminthic diseases. Models
Haplorhini
Helminthic diseases
hormones
Humans
Infectious diseases
Invertebrate Hormones - blood
Invertebrate Hormones - metabolism
Invertebrate Hormones - urine
Kinetics
Mass Spectrometry
Mass spectrum analysis
Medical sciences
Parasitic diseases
Radioimmunoassay
Rats
Schistosoma haematobium
Schistosoma haematobium - metabolism
Schistosoma mansoni
Schistosoma mansoni - metabolism
Schistosomiases
Schistosomiasis
Schistosomiasis - metabolism
Stereoisomerism
Technique, Drug evaluation and screening
Trematoda
trematode infections
Tropical medicine
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Description
Summary:Ecdysteroids produced by schistosomes are released in biological fluids of infected hosts. In the sera, the concentration of ecdysteroids correlates with the perimissiveness of the host to schistosome infection and its detection is available in the absence of positive parasitological tests. In the urine, ecdysteroid concentration decreases markedly after chemotherapy. 20-Hydroxyecdysone and its epimer were identified in the urine of infected patients using mass spectrometry. These data demonstrate for the first time that ecdysteroids are released by organisms. Moreover, they are potent molecules of parasite infection and can be used for parasite diagnosis.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(84)80253-7