Iodoamphetamine as a New Tracer for Local Cerebral Blood Flow in the Rat: Comparison with Isopropyliodoamphetamine

• Published in: Journal of cerebral blood flow and metabolism 1984-06, Vol.4 (2), p.270-274
• Main Authors: Rapin, Jean R., Le Poncin-Lafitte, Monique, Duterte, Dominique, Rips, Richard, Morier, Elisabeth, Lassen, Niels A.
• Format: Article
• Language: English
• Subjects: Amphetamines; Animals; Autoradiography; Biochemistry and metabolism; Biological and medical sciences; Central nervous system; Cerebrovascular Circulation; Fundamental and applied biological sciences. Psychology; Iodine Radioisotopes; Iofetamine; Rats; Rats, Inbred Strains; Vertebrates: nervous system and sense organs
• ISSN: 0271-678X; 1559-7016
• DOI: 10.1038/jcbfm.1984.37

Rats were injected with iodoamphetamine synthesized and labeled with 125I or with 125I-isopropyliodoamphetamine, a molecule of established value for the determination of local cerebral blood flow. The blood kinetics, tissue distribution, and brain uptake index for each tracer exhibited practically no differences. Autoradiographic quantification of the local cerebral blood flow, calculated according to the microsphere model, produced identical results for both molecules. However, compared with the values reported for other tracers, our values constituted an underestimation of white matter blood flow and a more real estimation of hippocampal flow. It is concluded from the brain uptake of the derivatives of both amphetamines during the first minutes following their injection that these tracers can be used as a chemical microembolus for the measurement of local cerebral blood flow.