An Inhibitor of Lipoxygenase, Nordihydroguaiaretic Acid, Shortens Actin Filaments

An inhibitor of lipoxygenase of arachidonic acid, nordihydroguaiaretic acid, shortens actin filaments, as judged by electron microscopic observation of negatively stained actin filaments, actin sedimentability and measurement of specific viscosity, at concentrations that inhibit the migration of pha...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 1984-01, Vol.95 (3), p.891-894
Main Authors: HIRATA, Masato, INAMITSU, Tetsuaki, HASHIMOTO, Toshihiko, KOGA, Toshitaka
Format: Article
Language:English
Subjects:
actin
Actins - metabolism
Analytical, structural and metabolic biochemistry
Animals
ATP
Biological and medical sciences
Catechols - pharmacology
Contractile proteins
electron microscopy
Fundamental and applied biological sciences. Psychology
Holoproteins
Lipoxygenase Inhibitors
Masoprocol
Microscopy, Electron
myosin
Myosins - metabolism
nordihydroguaiaretic acid
Proteins
Rabbits
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Summary:An inhibitor of lipoxygenase of arachidonic acid, nordihydroguaiaretic acid, shortens actin filaments, as judged by electron microscopic observation of negatively stained actin filaments, actin sedimentability and measurement of specific viscosity, at concentrations that inhibit the migration of phagocytic cells. At higher concentrations (more than 10 μM), nordihydroguaiaretic acid strikingly inhibits myosin ATPase activity. Thus nordihydroguaiaretic acid has a severe side effect on the cytoskeleton.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a134683