Immunopharmacologic Profiles of a Thiol Protease Inhibitor, L-Trans-Dicyclohexyl Epoxysuccinate

Ep-1, L-trans-Dicyclohexyl epoxysuccinate, is a synthetic and specific inhibitor of thiol proteases. The effects cf this inhibitor on some immunological parameters were examined in normal and immunity-impaired mice and rats. In the cultures of splenocytes obtained from the mice treated with Ep-1, it...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1984, Vol.34(3), pp.335-342
Main Authors: AMAMOTO, Toshiro, OKAZAKI, Tadayasu, KOMURASAKI, Toshi, OGUMA, Kiyoshi, TAMAI, Masaharu, HANADA, Kazunori, OMURA, Sadafumi
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Arthritis, Experimental - immunology
Cyclohexanes - pharmacology
Female
Hemolytic Plaque Technique
Hypersensitivity, Delayed - immunology
Lymphocyte Activation - drug effects
Lymphocytes - drug effects
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mitogens - pharmacology
Protease Inhibitors - pharmacology
Rats
Rats, Inbred Strains
Spleen - cytology
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Summary:Ep-1, L-trans-Dicyclohexyl epoxysuccinate, is a synthetic and specific inhibitor of thiol proteases. The effects cf this inhibitor on some immunological parameters were examined in normal and immunity-impaired mice and rats. In the cultures of splenocytes obtained from the mice treated with Ep-1, it enhanced the lymphocyte blast transformation induced by both suboptimal and optimal concentrations of concanavalin A (Con A) arid Lens culinaris (LC) . The in vivo administration of Ep-1 caused a depression of the plaque forming cells (PFC) for sheep red blood cell (SRBC) and enhanced the delayed-type hypersensitivity (DTH) for bovine serum albumin (BSA) as well as mixed lymphocytes cultures (MLC). Furthermore, Ep-1 demonstrated a preventive effect on adjuvant arthritic rats. The relevance of immunological regulation and the mode of action of Ep-1 as a thiol protease inhibitor are discussed in these findings.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.34.335