The effect of newborn chicks of oral inoculation of reovirus isolated from chickens with tenosynovitis

• Published in: Avian diseases 1987-07, Vol.31 (3), p.584-590
• Main Authors: Tang, K.N, Fletcher, O.J, Villegas, P
• Format: Article
• Language: English
• Subjects: ANIMAL DE LABORATOIRE; ANIMALES DE LABORATORIO; ANIMALES JOVENES; Animals; Bursa of Fabricius - pathology; CHICKENS; CHICKS; Inoculation; JEUNE ANIMAL; LABORATORY ANIMALS; Liver; Liver - pathology; Lymphocytes; MORTALIDAD; MORTALITE; MORTALITY; Myocardium - pathology; Necrosis; PATHOGENICITY; Plasma cells; PODER PATOGENO; POLLITO; POLLO; POULET; Poultry Diseases - microbiology; Poultry Diseases - pathology; POUSSIN; POUVOIR PATHOGENE; REOVIRIDAE; Reoviridae - pathogenicity; Reoviridae Infections - microbiology; Reoviridae Infections - pathology; Reoviridae Infections - veterinary; reovirus; Specific Pathogen-Free Organisms; Spleen - pathology; Stromal cells; Tendons - pathology; TENOSINOVITIS; TENOSYNOVITE; TENOSYNOVITIS; Tenosynovitis - microbiology; Tenosynovitis - pathology; Tenosynovitis - veterinary; Viruses; YOUNG ANIMALS
• ISSN: 0005-2086; 1938-4351
• DOI: 10.2307/1590744

Reovirus strain 176, isolated from chickens with tenosynovitis, was highly pathogenic following oral inoculation of 1-day-old specific-pathogen-free chicks. Disseminated lesions including hepatic necrosis, splenic lymphostromal cell hyperplasia, and bursal atrophy occurred on day 3 postinoculation (PI), followed by myocarditis on day 6 PI and by pericarditis and tenosynovitis on day 9 PI. Reovirus was isolated from the liver as early as day 1 PI, whereas significant neutralizing antibody was detected on day 13 PI. Mortality occurred from day 4 to day 7 PI, and the death of birds was associated with the severity of hepatic necrosis. The occurrence of tenosynovitis in virus-inoculated birds was subclinical. /// La cepa de reovirus 176, aislada de pollos con tenosinovitis, fué altamente patógena después de la inoculación oral de pollos libres de patógenos de un día de edad. Tres días después de la inoculación, las lesiones incluyeron necrosis hepática, hiperplasia celular linfoestromática esplénica y atrofia de la bolsa. Al sexto día se observó miocarditis y al noveno día pericarditis y tenosinovitis. Se aisló el reovirus del hígado a partir del primer día después de la inoculación. Niveles significantes de anticuerpos neutralizantes fueron observados el día 13 después de la inoculación. La mortalidad ocurrió entre los días 4 y 7, asociandose con la severidad de la necrosis hepática. La ocurrencia de tenosinovitis en los pollos inoculados fué subclínica.