Barrier pressure and muscle relaxants. Comparison of the effects of pancuronium and vecuronium on the lower œsophageal sphincter

The effects of pancuronium and vecuronium on the lower oesophageal sphincter pressure were studied in 24 healthy patients anaesthetised with 0.5% halothane in nitrous oxide and oxygen. Following pancuronium 0.1 mg/kg intravenously, there was a significant increase in barrier pressure from a control...

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Bibliographic Details
Published in:Anaesthesia 1984-05, Vol.39 (5), p.412-415
Main Authors: HUNT, P. C. W, COTTON, B. R, SMITH, G
Format: Article
Language:English
Subjects:
Anesthesia, Inhalation
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Blood Pressure - drug effects
Esophagogastric Junction - drug effects
Female
Halothane
Heart Rate - drug effects
Humans
Medical sciences
Neuromuscular Blocking Agents - pharmacology
Neuropharmacology
Nitrous Oxide
Pancuronium - analogs & derivatives
Pancuronium - pharmacology
Pharmacology. Drug treatments
Pressure
Random Allocation
Stomach - physiology
Vecuronium Bromide
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Summary:The effects of pancuronium and vecuronium on the lower oesophageal sphincter pressure were studied in 24 healthy patients anaesthetised with 0.5% halothane in nitrous oxide and oxygen. Following pancuronium 0.1 mg/kg intravenously, there was a significant increase in barrier pressure from a control value of 2.0 (SEM 0.14) kPa to 3.0 (SEM 0.27) kPa 1 minute after injection (p less than 0.05). This increase was sustained throughout the 15 minute period of recording and was accompanied by a significant increase in heart rate (p less than 0.001). Following administration of vecuronium 0.1 mg/kg intravenously there was an initial modest, though not significant increase in barrier pressure. This increase was significant (p less than 0.05) at 15 minutes. There were no cardiovascular changes following vecuronium.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1984.tb07306.x