Cytogenetic Studies and In Vitro Colony Growth in Patients With Mastocytosis

Cytogenetic analysis of bone marrow cells and in vitro growth for bone marrow granulocytic-macrophage stem cells have been performed in 13 patients with mastocytosis, six with systemic mastocytosis, and seven with urticaria pigmentosa. Clones with chromosome abnormalities were found in five patients...

Full description

Saved in:
Bibliographic Details
Published in:Blood 1987-12, Vol.70 (6), p.1928-1932
Main Authors: Swolin, Birgitta, Rödjer, Stig, Roupe, Gösta
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Bone Marrow - pathology
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 9
Exact sciences and technology
Granulocytes - physiology
Hematologic and hematopoietic diseases
Humans
Karyotyping
Macrophages - physiology
Mast Cells - pathology
Mastocytosis - genetics
Mastocytosis - pathology
Medical sciences
Other diseases. Hematologic involvement in other diseases
Other techniques and industries
Urticaria Pigmentosa - pathology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cytogenetic analysis of bone marrow cells and in vitro growth for bone marrow granulocytic-macrophage stem cells have been performed in 13 patients with mastocytosis, six with systemic mastocytosis, and seven with urticaria pigmentosa. Clones with chromosome abnormalities were found in five patients. The number of clusters and/or colonies after seven days in culture was increased in seven patients, compared with the growth in a control group. Three patients with chromosome abnormalities showed an abnormal growth pattern, yet exhibited normal peripheral blood values. Two patients with systemic mastocytosis had clones with chromosome abnormalities and some abnormal hematological values. The proportion of patients with chromosome abnormalities and an abnormal growth pattern was higher among these patients with mastocytosis than in healthy control subjects. These results may be of interest when discussing the origin of mast cell disorders and indicate an association with the myeloproliferative disorders.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V70.6.1928.1928