The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia

A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or wheth...

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Bibliographic Details
Published in:Cancer 1987-12, Vol.60 (12), p.3049-3055
Main Authors: Saul, Scott H., Titelbaum, David S., Gansler, Ted S., Varello, Michael, Burke, Dana R., Atkinson, Barbara F., Rosato, Ernest F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hyperplasia - complications
Liver - pathology
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Tumors
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Description
Summary:A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or whether FNH is a typical response to this vascular variant of hepatocellular carcinoma (HCC). The FNH region, which is peripheral, may be biopsied to exclude the underlying carcinoma, and thus lead to inadequate therapy. Previous reports of this association are reviewed.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19871215)60:12<3049::AID-CNCR2820601232>3.0.CO;2-M