The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia

A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or wheth...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1987-12, Vol.60 (12), p.3049-3055
Main Authors: Saul, Scott H., Titelbaum, David S., Gansler, Ted S., Varello, Michael, Burke, Dana R., Atkinson, Barbara F., Rosato, Ernest F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hyperplasia - complications
Liver - pathology
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c4162-e4c438722a78abed26b5e2bf3a5df007e02b810ee7ef2711c7cd8fdf34f19f8b3
container_end_page 3055
container_issue 12
container_start_page 3049
container_title Cancer
container_volume 60
creator Saul, Scott H.
Titelbaum, David S.
Gansler, Ted S.
Varello, Michael
Burke, Dana R.
Atkinson, Barbara F.
Rosato, Ernest F.
description A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or whether FNH is a typical response to this vascular variant of hepatocellular carcinoma (HCC). The FNH region, which is peripheral, may be biopsied to exclude the underlying carcinoma, and thus lead to inadequate therapy. Previous reports of this association are reviewed.
doi_str_mv 10.1002/1097-0142(19871215)60:12<3049::AID-CNCR2820601232>3.0.CO;2-M
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81107750</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81107750</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4162-e4c438722a78abed26b5e2bf3a5df007e02b810ee7ef2711c7cd8fdf34f19f8b3</originalsourceid><addsrcrecordid>eNqVkV-L1DAUxYMo67j6EYQ-iOhDx5ukbdpRhKXrn4FdB2QFH4RwmyZOpG1q0nGZb2_qjAP6IPgUbs7vXg7nEHJJYUkB2AsKlUiBZuwZrUpBGc2fF7Ci7BWHrFqtLtaXaf2h_shKBgVQxtlrvoRlvXnJ0us7ZHFav0sWAFCmecY_3ycPQvgWR8FyfkbO4nIGjC-IvtnqxNjGuw573XXokx_oLQ5T4kyy1SNOTsX_3awo9MoOrsdlsp5CgiE4ZXGybkhu7bRNjFPYJYNrf9Hb_aj92GGw-JDcM9gF_ej4npNPb9_c1O_Tq827dX1xlaqMFizVmcp4KRhDUWKjW1Y0uWaN4Zi3JnrXwJqSgtZCGyYoVUK1pWkNzwytTNnwc_L0cHf07vtOh0n2Nsz2cdBuF2RJKQiRQwS_HEDlXQheGzl626PfSwpybkHOMco5Rvm7BVlEicm5BSljC_LPFiSXIOuNZPI6nn989LFret2ejh9jj_qTo44hRmY8DsqGEyYyXlRixr4esFvb6f1_Wvynw78U_hOZDrO4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81107750</pqid></control><display><type>article</type><title>The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia</title><source>EZB Free E-Journals</source><creator>Saul, Scott H. ; Titelbaum, David S. ; Gansler, Ted S. ; Varello, Michael ; Burke, Dana R. ; Atkinson, Barbara F. ; Rosato, Ernest F.</creator><creatorcontrib>Saul, Scott H. ; Titelbaum, David S. ; Gansler, Ted S. ; Varello, Michael ; Burke, Dana R. ; Atkinson, Barbara F. ; Rosato, Ernest F.</creatorcontrib><description>A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or whether FNH is a typical response to this vascular variant of hepatocellular carcinoma (HCC). The FNH region, which is peripheral, may be biopsied to exclude the underlying carcinoma, and thus lead to inadequate therapy. Previous reports of this association are reviewed.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19871215)60:12&lt;3049::AID-CNCR2820601232&gt;3.0.CO;2-M</identifier><identifier>PMID: 2824023</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Biological and medical sciences ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hyperplasia - complications ; Liver - pathology ; Liver Neoplasms - etiology ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Tumors</subject><ispartof>Cancer, 1987-12, Vol.60 (12), p.3049-3055</ispartof><rights>Copyright © 1987 American Cancer Society</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4162-e4c438722a78abed26b5e2bf3a5df007e02b810ee7ef2711c7cd8fdf34f19f8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=7436973$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2824023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saul, Scott H.</creatorcontrib><creatorcontrib>Titelbaum, David S.</creatorcontrib><creatorcontrib>Gansler, Ted S.</creatorcontrib><creatorcontrib>Varello, Michael</creatorcontrib><creatorcontrib>Burke, Dana R.</creatorcontrib><creatorcontrib>Atkinson, Barbara F.</creatorcontrib><creatorcontrib>Rosato, Ernest F.</creatorcontrib><title>The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or whether FNH is a typical response to this vascular variant of hepatocellular carcinoma (HCC). The FNH region, which is peripheral, may be biopsied to exclude the underlying carcinoma, and thus lead to inadequate therapy. Previous reports of this association are reviewed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hyperplasia - complications</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqVkV-L1DAUxYMo67j6EYQ-iOhDx5ukbdpRhKXrn4FdB2QFH4RwmyZOpG1q0nGZb2_qjAP6IPgUbs7vXg7nEHJJYUkB2AsKlUiBZuwZrUpBGc2fF7Ci7BWHrFqtLtaXaf2h_shKBgVQxtlrvoRlvXnJ0us7ZHFav0sWAFCmecY_3ycPQvgWR8FyfkbO4nIGjC-IvtnqxNjGuw573XXokx_oLQ5T4kyy1SNOTsX_3awo9MoOrsdlsp5CgiE4ZXGybkhu7bRNjFPYJYNrf9Hb_aj92GGw-JDcM9gF_ej4npNPb9_c1O_Tq827dX1xlaqMFizVmcp4KRhDUWKjW1Y0uWaN4Zi3JnrXwJqSgtZCGyYoVUK1pWkNzwytTNnwc_L0cHf07vtOh0n2Nsz2cdBuF2RJKQiRQwS_HEDlXQheGzl626PfSwpybkHOMco5Rvm7BVlEicm5BSljC_LPFiSXIOuNZPI6nn989LFret2ejh9jj_qTo44hRmY8DsqGEyYyXlRixr4esFvb6f1_Wvynw78U_hOZDrO4</recordid><startdate>19871215</startdate><enddate>19871215</enddate><creator>Saul, Scott H.</creator><creator>Titelbaum, David S.</creator><creator>Gansler, Ted S.</creator><creator>Varello, Michael</creator><creator>Burke, Dana R.</creator><creator>Atkinson, Barbara F.</creator><creator>Rosato, Ernest F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871215</creationdate><title>The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia</title><author>Saul, Scott H. ; Titelbaum, David S. ; Gansler, Ted S. ; Varello, Michael ; Burke, Dana R. ; Atkinson, Barbara F. ; Rosato, Ernest F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4162-e4c438722a78abed26b5e2bf3a5df007e02b810ee7ef2711c7cd8fdf34f19f8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hyperplasia - complications</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saul, Scott H.</creatorcontrib><creatorcontrib>Titelbaum, David S.</creatorcontrib><creatorcontrib>Gansler, Ted S.</creatorcontrib><creatorcontrib>Varello, Michael</creatorcontrib><creatorcontrib>Burke, Dana R.</creatorcontrib><creatorcontrib>Atkinson, Barbara F.</creatorcontrib><creatorcontrib>Rosato, Ernest F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saul, Scott H.</au><au>Titelbaum, David S.</au><au>Gansler, Ted S.</au><au>Varello, Michael</au><au>Burke, Dana R.</au><au>Atkinson, Barbara F.</au><au>Rosato, Ernest F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1987-12-15</date><risdate>1987</risdate><volume>60</volume><issue>12</issue><spage>3049</spage><epage>3055</epage><pages>3049-3055</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>A case of fibrolamellar hepatocellular carcinoma (FL‐HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL‐HCC rarely arises in preexisting FNH, or whether FNH is a typical response to this vascular variant of hepatocellular carcinoma (HCC). The FNH region, which is peripheral, may be biopsied to exclude the underlying carcinoma, and thus lead to inadequate therapy. Previous reports of this association are reviewed.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2824023</pmid><doi>10.1002/1097-0142(19871215)60:12&lt;3049::AID-CNCR2820601232&gt;3.0.CO;2-M</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0008-543X
ispartof Cancer, 1987-12, Vol.60 (12), p.3049-3055
issn 0008-543X
1097-0142
language eng
recordid cdi_proquest_miscellaneous_81107750
source EZB Free E-Journals
subjects Adult
Biological and medical sciences
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hyperplasia - complications
Liver - pathology
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Tumors
title The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T21%3A36%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20fibrolamellar%20variant%20of%20hepatocellular%20carcinoma.%20Its%20association%20with%20focal%20nodular%20hyperplasia&rft.jtitle=Cancer&rft.au=Saul,%20Scott%20H.&rft.date=1987-12-15&rft.volume=60&rft.issue=12&rft.spage=3049&rft.epage=3055&rft.pages=3049-3055&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/1097-0142(19871215)60:12%3C3049::AID-CNCR2820601232%3E3.0.CO;2-M&rft_dat=%3Cproquest_cross%3E81107750%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4162-e4c438722a78abed26b5e2bf3a5df007e02b810ee7ef2711c7cd8fdf34f19f8b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=81107750&rft_id=info:pmid/2824023&rfr_iscdi=true