Transdermal administration of nicotine

The physiological response to nicotine topically applied to the skin was measured in an adult male volunteer. Nicotine base (9 mg) was applied in a 30% aqueous solution to intact skin on the underside of the forearm. Salivary nicotine, heart rate and blood pressure were monitored for 12 h after appl...

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Bibliographic Details
Published in:Drug and alcohol dependence 1984-05, Vol.13 (3), p.209-213
Main Authors: Rose, J.E., Jarvik, M.E., Rose, K.D.
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Biological and medical sciences
Blood Pressure - drug effects
Cigarette smoking
Heart Rate - drug effects
Humans
Male
Medical sciences
Nicotine
Nicotine - administration & dosage
Nicotine - metabolism
Saliva - metabolism
Skin Absorption
Tobacco, tobacco smoking
Toxicology
Transdermal administration
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Summary:The physiological response to nicotine topically applied to the skin was measured in an adult male volunteer. Nicotine base (9 mg) was applied in a 30% aqueous solution to intact skin on the underside of the forearm. Salivary nicotine, heart rate and blood pressure were monitored for 12 h after application of the nicotine. Within 30 min a significant level of nicotine was detected in the saliva (50 ng/ml), pulse had risen by 15 beats/min and systolic blood pressure had risen 10 mmHg. Nicotine levels remained elevated for 2 h and were comparable to levels of nicotine produced by cigarette smoking. Because previous research has shown nicotine to suppress smoking behavior, it may be fruitful to examine transdermal administration of nicotine as a smoking reduction and cessation aid.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(84)90061-9