Effect of seminal plasmin on rRNA synthesis in Saccharomyces cerevisiae

Seminal plasmin, the highly basic, antimicrobial protein, isolated from bull semen, was found to inhibit the transcription of ribosomal RNA in yeast. Protein synthesis and processing of rRNA remained unaffected. Seminal plasmin appears to be useful for studies of the biosynthesis of yeast rRNA in pu...

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Bibliographic Details
Published in:FEBS letters 1984-06, Vol.172 (1), p.21-24
Main Authors: Venkov, Pencho, Scheit, Karl Heinz
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Kinetics
Molecular and cellular biology
Molecular genetics
Mutation
Nucleic Acid Precursors - metabolism
Proteins - pharmacology
RNA Precursors
RNA, Fungal - biosynthesis
RNA, Ribosomal - biosynthesis
RNA, Ribosomal - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Seminal Vesicle Secretory Proteins
Transcription, Genetic - drug effects
Transcription. Transcription factor. Splicing. Rna processing
Uracil - metabolism
Yeast rRNA synthesis Seminal plasmin Inhibition
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Summary:Seminal plasmin, the highly basic, antimicrobial protein, isolated from bull semen, was found to inhibit the transcription of ribosomal RNA in yeast. Protein synthesis and processing of rRNA remained unaffected. Seminal plasmin appears to be useful for studies of the biosynthesis of yeast rRNA in pulsechase experiments.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(84)80864-9