In the search for new anticancer drugs. VII: Platinum complexes of diaziridines and azetidine

Three new diaziridine platinum(II) complexes (4a)-(4c), and a new azetidine platinum(II) complex (3b) were synthesized and tested against the lymphocytic leukemia P388 in mice. (formula; see text) Moderate to good activity was found for all compounds as evidenced by a T/C value of 162 at a dose of 3...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1984, Vol.107 (3), p.217-220
Main Authors: SOSNOVSKY, G, LUKSZO, J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - therapeutic use
Azetidines - chemical synthesis
Azetidines - therapeutic use
Azetines - chemical synthesis
Aziridines - chemical synthesis
Aziridines - therapeutic use
Azirines - chemical synthesis
Biological and medical sciences
General pharmacology
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Male
Medical sciences
Mice
Mice, Inbred Strains
Organoplatinum Compounds - chemical synthesis
Organoplatinum Compounds - therapeutic use
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Structure-Activity Relationship
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three new diaziridine platinum(II) complexes (4a)-(4c), and a new azetidine platinum(II) complex (3b) were synthesized and tested against the lymphocytic leukemia P388 in mice. (formula; see text) Moderate to good activity was found for all compounds as evidenced by a T/C value of 162 at a dose of 32 mg/kg for (3b), 190 at a dose of 32 mg/kg for (4a), 139 at a dose of 4 mg/kg for (4b), and 142 at a dose of 20 mg/kg for (4c).
ISSN:0171-5216
1432-1335
DOI:10.1007/BF01032610