PENETRATION OF CEFBUPERAZONE, A NEW CEPHAMYCIN ANTIBIOTIC, INTO HUMAN PERITONEAL EXUDATE

Pharmacokinetic studies were carried out on cefbuperazone (CBPZ) in 9 patients postoperating under-going drainage. The concentration of CBPZ in serum and peritoneal exudate after one shot intravenous administration of 1g was measured by bioassay and calculated respectively by two-and one-compartment...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of antibiotics 1984/02/25, Vol.37(2), pp.261-266
Main Authors: WATANABE, Yozo, GONDA, ATSUFUMI, KIDOKORO, TSUTOMU
Format: Article
Language:Japanese
Subjects:
Adult
Aged
Ascitic Fluid - metabolism
Cephamycins - administration & dosage
Cephamycins - blood
Cephamycins - metabolism
Female
Half-Life
Humans
Injections, Intravenous
Kinetics
Male
Middle Aged
Models, Biological
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pharmacokinetic studies were carried out on cefbuperazone (CBPZ) in 9 patients postoperating under-going drainage. The concentration of CBPZ in serum and peritoneal exudate after one shot intravenous administration of 1g was measured by bioassay and calculated respectively by two-and one-compartment open model. The results obtained were as follows: 1. The pharmacokinetic parameters calculated from the serum levels were compared to those reported previously; T1/2=101min., Vd=4.06L and Cl=76ml/min. 2. The simulation curve of the peritoneal exudate level fit fairly with the mean values of 6 patients. It appeared that CBPZ penetrated somewhat slowly into peritoneal exudate with the peak value of 27.05μg/ml at about 1 hour after the administration. The exudate levels thereafter declined more slowly than the serum ones (T1/2=134min.). It was 6.2μg/ml even at 6 hours after the administration.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.261