[$^{3}$H]Lysergic Acid Diethylamide: Cellular Autoradiographic Localization in Rat Brain

Intravenous administration of [$^{3}$H]lysergic acid diethylamide (LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Auto-radiographic methods were used to differentiate free and bound [$^{3}$H]LSD in brain tissue. Free [$^{3}$H]LSD was generally distributed in the pi...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1971-09, Vol.173 (4001), p.1022-1024
Main Authors: Diab, I. M., Freedman, D. X., Roth, L. J.
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Binding Sites
Brain
Brain Chemistry
Caudate Nucleus - analysis
Cerebellum
Cerebellum - analysis
Cerebral Cortex - analysis
Choroid plexus
Choroid Plexus - analysis
Freeze Drying
Hippocampus
Hippocampus - analysis
Histocytochemistry
Histology
Injections, Intravenous
LSD
Lysergic Acid Diethylamide - administration & dosage
Lysergic Acid Diethylamide - analysis
Lysergic Acid Diethylamide - metabolism
Mesencephalon - analysis
Midbrain
Neurons
Olivary Nucleus - analysis
Pineal gland
Pineal Gland - analysis
Pituitary Gland - analysis
Purkinje cells
Purkinje Cells - analysis
Rats
Superior Colliculi - analysis
Tegmentum Mesencephali - analysis
Time Factors
Tritium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intravenous administration of [$^{3}$H]lysergic acid diethylamide (LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Auto-radiographic methods were used to differentiate free and bound [$^{3}$H]LSD in brain tissue. Free [$^{3}$H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus, and choroid plexus. Bound [$^{3}$H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla, as well as in choroid plexus epithelium.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.173.4001.1022