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[$^{3}$H]Lysergic Acid Diethylamide: Cellular Autoradiographic Localization in Rat Brain
Intravenous administration of [$^{3}$H]lysergic acid diethylamide (LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Auto-radiographic methods were used to differentiate free and bound [$^{3}$H]LSD in brain tissue. Free [$^{3}$H]LSD was generally distributed in the pi...
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| Published in: | Science (American Association for the Advancement of Science) 1971-09, Vol.173 (4001), p.1022-1024 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c356t-b14c70cd6802f67c648b49adb14aa3b83dd643fa3442d6c8ca6c8c691e9aac0e3 |
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| cites | cdi_FETCH-LOGICAL-c356t-b14c70cd6802f67c648b49adb14aa3b83dd643fa3442d6c8ca6c8c691e9aac0e3 |
| container_end_page | 1024 |
| container_issue | 4001 |
| container_start_page | 1022 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 173 |
| creator | Diab, I. M. Freedman, D. X. Roth, L. J. |
| description | Intravenous administration of [$^{3}$H]lysergic acid diethylamide (LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Auto-radiographic methods were used to differentiate free and bound [$^{3}$H]LSD in brain tissue. Free [$^{3}$H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus, and choroid plexus. Bound [$^{3}$H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla, as well as in choroid plexus epithelium. |
| doi_str_mv | 10.1126/science.173.4001.1022 |
| format | article |
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Bound [$^{3}$H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla, as well as in choroid plexus epithelium.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.173.4001.1022</identifier><identifier>PMID: 5098960</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Autoradiography ; Binding Sites ; Brain ; Brain Chemistry ; Caudate Nucleus - analysis ; Cerebellum ; Cerebellum - analysis ; Cerebral Cortex - analysis ; Choroid plexus ; Choroid Plexus - analysis ; Freeze Drying ; Hippocampus ; Hippocampus - analysis ; Histocytochemistry ; Histology ; Injections, Intravenous ; LSD ; Lysergic Acid Diethylamide - administration & dosage ; Lysergic Acid Diethylamide - analysis ; Lysergic Acid Diethylamide - metabolism ; Mesencephalon - analysis ; Midbrain ; Neurons ; Olivary Nucleus - analysis ; Pineal gland ; Pineal Gland - analysis ; Pituitary Gland - analysis ; Purkinje cells ; Purkinje Cells - analysis ; Rats ; Superior Colliculi - analysis ; Tegmentum Mesencephali - analysis ; Time Factors ; Tritium</subject><ispartof>Science (American Association for the Advancement of Science), 1971-09, Vol.173 (4001), p.1022-1024</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b14c70cd6802f67c648b49adb14aa3b83dd643fa3442d6c8ca6c8c691e9aac0e3</citedby><cites>FETCH-LOGICAL-c356t-b14c70cd6802f67c648b49adb14aa3b83dd643fa3442d6c8ca6c8c691e9aac0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2884,2885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5098960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diab, I. M.</creatorcontrib><creatorcontrib>Freedman, D. X.</creatorcontrib><creatorcontrib>Roth, L. J.</creatorcontrib><title>[$^{3}$H]Lysergic Acid Diethylamide: Cellular Autoradiographic Localization in Rat Brain</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Intravenous administration of [$^{3}$H]lysergic acid diethylamide (LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Auto-radiographic methods were used to differentiate free and bound [$^{3}$H]LSD in brain tissue. Free [$^{3}$H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus, and choroid plexus. Bound [$^{3}$H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla, as well as in choroid plexus epithelium.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Binding Sites</subject><subject>Brain</subject><subject>Brain Chemistry</subject><subject>Caudate Nucleus - analysis</subject><subject>Cerebellum</subject><subject>Cerebellum - analysis</subject><subject>Cerebral Cortex - analysis</subject><subject>Choroid plexus</subject><subject>Choroid Plexus - analysis</subject><subject>Freeze Drying</subject><subject>Hippocampus</subject><subject>Hippocampus - analysis</subject><subject>Histocytochemistry</subject><subject>Histology</subject><subject>Injections, Intravenous</subject><subject>LSD</subject><subject>Lysergic Acid Diethylamide - administration & dosage</subject><subject>Lysergic Acid Diethylamide - analysis</subject><subject>Lysergic Acid Diethylamide - metabolism</subject><subject>Mesencephalon - analysis</subject><subject>Midbrain</subject><subject>Neurons</subject><subject>Olivary Nucleus - analysis</subject><subject>Pineal gland</subject><subject>Pineal Gland - analysis</subject><subject>Pituitary Gland - analysis</subject><subject>Purkinje cells</subject><subject>Purkinje Cells - analysis</subject><subject>Rats</subject><subject>Superior Colliculi - analysis</subject><subject>Tegmentum Mesencephali - analysis</subject><subject>Time Factors</subject><subject>Tritium</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><recordid>eNpFkE9LAzEQxYMoWqvfwMIeiretk81uNuut1r9QEERBEA3TJG1Ttrs12T1U8bub0qKXGZj33szwI6RHYUBpwi-8sqZSZkBzNkgB6IBCkuyRDoUii4sE2D7pADAeC8izI3Ls_QIgaAU7JIcZFKLg0CGvb_2Pb_bTv38fr71xM6uiobI6uramma9LXFptLqORKcu2RBcN26Z2qG09c7iaB_O4VljaL2xsXUW2ip6wia4c2uqEHEyx9OZ017vk5fbmeXQfjx_vHkbDcaxYxpt4QlOVg9JcQDLlueKpmKQF6jBHZBPBtOYpmyJL00RzJRRuCi-oKRAVGNYl59u9K1d_tsY3cmm9Cv9iZerWS0Epg0ywYMy2RuVq752ZypWzS3RrSUFuiModURmIyg1RuSEacr3dgXayNPovtUMY9LOtvvCBzf_SnCWJyNkv3WB9jw</recordid><startdate>19710910</startdate><enddate>19710910</enddate><creator>Diab, I. M.</creator><creator>Freedman, D. X.</creator><creator>Roth, L. J.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19710910</creationdate><title>[$^{3}$H]Lysergic Acid Diethylamide: Cellular Autoradiographic Localization in Rat Brain</title><author>Diab, I. M. ; Freedman, D. X. ; Roth, L. 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M.</creatorcontrib><creatorcontrib>Freedman, D. X.</creatorcontrib><creatorcontrib>Roth, L. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diab, I. M.</au><au>Freedman, D. X.</au><au>Roth, L. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[$^{3}$H]Lysergic Acid Diethylamide: Cellular Autoradiographic Localization in Rat Brain</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1971-09-10</date><risdate>1971</risdate><volume>173</volume><issue>4001</issue><spage>1022</spage><epage>1024</epage><pages>1022-1024</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Intravenous administration of [$^{3}$H]lysergic acid diethylamide (LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Auto-radiographic methods were used to differentiate free and bound [$^{3}$H]LSD in brain tissue. Free [$^{3}$H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus, and choroid plexus. Bound [$^{3}$H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla, as well as in choroid plexus epithelium.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>5098960</pmid><doi>10.1126/science.173.4001.1022</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1971-09, Vol.173 (4001), p.1022-1024 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81130583 |
| source | American Association for the Advancement of Science |
| subjects | Animals Autoradiography Binding Sites Brain Brain Chemistry Caudate Nucleus - analysis Cerebellum Cerebellum - analysis Cerebral Cortex - analysis Choroid plexus Choroid Plexus - analysis Freeze Drying Hippocampus Hippocampus - analysis Histocytochemistry Histology Injections, Intravenous LSD Lysergic Acid Diethylamide - administration & dosage Lysergic Acid Diethylamide - analysis Lysergic Acid Diethylamide - metabolism Mesencephalon - analysis Midbrain Neurons Olivary Nucleus - analysis Pineal gland Pineal Gland - analysis Pituitary Gland - analysis Purkinje cells Purkinje Cells - analysis Rats Superior Colliculi - analysis Tegmentum Mesencephali - analysis Time Factors Tritium |
| title | [$^{3}$H]Lysergic Acid Diethylamide: Cellular Autoradiographic Localization in Rat Brain |
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