Loading…

Growth Effects of Vanadium in the Rat

Vanadium is necessary for growing rats raised inside trace element-controlled, all plastic isolators on a highly purified amino acid diet. Addition of vanadium to the diet enhances growth by over 40 percent. A nearly optimum effect is obtained with 10 micrograms of vanadium per 100 grams of diet in...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 1971-10, Vol.174 (4007), p.426-428
Main Authors:	Schwarz, Klaus, Milne, David B.
Format:	Article
Language:	English
Subjects:	Amino acids Animals Body Weight Diet Dietary trace elements Growth - drug effects Nutritional Requirements Oxidation Rats Salts Sodium Sulfates Vanadates Vanadium Vanadium - administration & dosage Vanadium - pharmacology
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093
cites	cdi_FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093
container_end_page	428
container_issue	4007
container_start_page	426
container_title	Science (American Association for the Advancement of Science)
container_volume	174
creator	Schwarz, Klaus Milne, David B.
description	Vanadium is necessary for growing rats raised inside trace element-controlled, all plastic isolators on a highly purified amino acid diet. Addition of vanadium to the diet enhances growth by over 40 percent. A nearly optimum effect is obtained with 10 micrograms of vanadium per 100 grams of diet in (0.1 part per million), supplied in the form of sodium orthovanadate, as seen from series of tests with levels ranging from 1 to 5 micrograms per 100 grams of diet. Different vanadium compounds show different potencies: sodium orthovanadate was effective, metavanadate less active, and pyrovanadate without activity. Tetravalent vanadium, supplied as vanadyl sulfate or acetate, was utilized but produced smaller responses. The amounts of vanadium required are those normally found in tissues and nutrients.
doi_str_mv	10.1126/science.174.4007.426
format	article
fullrecord	<record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_81135659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1731776</jstor_id><sourcerecordid>1731776</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093</originalsourceid><addsrcrecordid>eNpFkE1Lw0AURQdRaq3-gwrZ6C7xvcz3UkqtQkEQdTtMJjM0pWlqJkH896Y06OrxuPeexSFkjpAh5uIhusrvnc9QsowByIzl4oxMETRPdQ70nEwBqEgVSH5JrmLcAgyZphMy4QNh-KbkbtU2390mWYbgXReTJiSfdm_Lqq-Tap90G5-82e6aXAS7i_5mvDPy8bR8Xzyn69fVy-JxnTqGukslLYGJXCmboyzLsqDC08Khl4oJpoICoWRwjgssco6FCtyiBtR5WWgBms7I_Yl7aJuv3sfO1FV0freze9_00ShEygU_Ftmp6NomxtYHc2ir2rY_BsEc7ZjRjhnsmKMdM9gZZrcjvy9qX_6NRh1DPj_l29g17T9TUpRS0F_dz2in</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81135659</pqid></control><display><type>article</type><title>Growth Effects of Vanadium in the Rat</title><source>American Association for the Advancement of Science</source><source>JSTOR Archival Journals and Primary Sources Collection</source><creator>Schwarz, Klaus ; Milne, David B.</creator><creatorcontrib>Schwarz, Klaus ; Milne, David B.</creatorcontrib><description>Vanadium is necessary for growing rats raised inside trace element-controlled, all plastic isolators on a highly purified amino acid diet. Addition of vanadium to the diet enhances growth by over 40 percent. A nearly optimum effect is obtained with 10 micrograms of vanadium per 100 grams of diet in (0.1 part per million), supplied in the form of sodium orthovanadate, as seen from series of tests with levels ranging from 1 to 5 micrograms per 100 grams of diet. Different vanadium compounds show different potencies: sodium orthovanadate was effective, metavanadate less active, and pyrovanadate without activity. Tetravalent vanadium, supplied as vanadyl sulfate or acetate, was utilized but produced smaller responses. The amounts of vanadium required are those normally found in tissues and nutrients.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.174.4007.426</identifier><identifier>PMID: 5112000</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Amino acids ; Animals ; Body Weight ; Diet ; Dietary trace elements ; Growth - drug effects ; Nutritional Requirements ; Oxidation ; Rats ; Salts ; Sodium ; Sulfates ; Vanadates ; Vanadium ; Vanadium - administration & dosage ; Vanadium - pharmacology</subject><ispartof>Science (American Association for the Advancement of Science), 1971-10, Vol.174 (4007), p.426-428</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093</citedby><cites>FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1731776$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1731776$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,2871,2872,27901,27902,58213,58446</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5112000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, Klaus</creatorcontrib><creatorcontrib>Milne, David B.</creatorcontrib><title>Growth Effects of Vanadium in the Rat</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Vanadium is necessary for growing rats raised inside trace element-controlled, all plastic isolators on a highly purified amino acid diet. Addition of vanadium to the diet enhances growth by over 40 percent. A nearly optimum effect is obtained with 10 micrograms of vanadium per 100 grams of diet in (0.1 part per million), supplied in the form of sodium orthovanadate, as seen from series of tests with levels ranging from 1 to 5 micrograms per 100 grams of diet. Different vanadium compounds show different potencies: sodium orthovanadate was effective, metavanadate less active, and pyrovanadate without activity. Tetravalent vanadium, supplied as vanadyl sulfate or acetate, was utilized but produced smaller responses. The amounts of vanadium required are those normally found in tissues and nutrients.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Diet</subject><subject>Dietary trace elements</subject><subject>Growth - drug effects</subject><subject>Nutritional Requirements</subject><subject>Oxidation</subject><subject>Rats</subject><subject>Salts</subject><subject>Sodium</subject><subject>Sulfates</subject><subject>Vanadates</subject><subject>Vanadium</subject><subject>Vanadium - administration & dosage</subject><subject>Vanadium - pharmacology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><recordid>eNpFkE1Lw0AURQdRaq3-gwrZ6C7xvcz3UkqtQkEQdTtMJjM0pWlqJkH896Y06OrxuPeexSFkjpAh5uIhusrvnc9QsowByIzl4oxMETRPdQ70nEwBqEgVSH5JrmLcAgyZphMy4QNh-KbkbtU2390mWYbgXReTJiSfdm_Lqq-Tap90G5-82e6aXAS7i_5mvDPy8bR8Xzyn69fVy-JxnTqGukslLYGJXCmboyzLsqDC08Khl4oJpoICoWRwjgssco6FCtyiBtR5WWgBms7I_Yl7aJuv3sfO1FV0freze9_00ShEygU_Ftmp6NomxtYHc2ir2rY_BsEc7ZjRjhnsmKMdM9gZZrcjvy9qX_6NRh1DPj_l29g17T9TUpRS0F_dz2in</recordid><startdate>19711022</startdate><enddate>19711022</enddate><creator>Schwarz, Klaus</creator><creator>Milne, David B.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19711022</creationdate><title>Growth Effects of Vanadium in the Rat</title><author>Schwarz, Klaus ; Milne, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Diet</topic><topic>Dietary trace elements</topic><topic>Growth - drug effects</topic><topic>Nutritional Requirements</topic><topic>Oxidation</topic><topic>Rats</topic><topic>Salts</topic><topic>Sodium</topic><topic>Sulfates</topic><topic>Vanadates</topic><topic>Vanadium</topic><topic>Vanadium - administration & dosage</topic><topic>Vanadium - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwarz, Klaus</creatorcontrib><creatorcontrib>Milne, David B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwarz, Klaus</au><au>Milne, David B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth Effects of Vanadium in the Rat</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1971-10-22</date><risdate>1971</risdate><volume>174</volume><issue>4007</issue><spage>426</spage><epage>428</epage><pages>426-428</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Vanadium is necessary for growing rats raised inside trace element-controlled, all plastic isolators on a highly purified amino acid diet. Addition of vanadium to the diet enhances growth by over 40 percent. A nearly optimum effect is obtained with 10 micrograms of vanadium per 100 grams of diet in (0.1 part per million), supplied in the form of sodium orthovanadate, as seen from series of tests with levels ranging from 1 to 5 micrograms per 100 grams of diet. Different vanadium compounds show different potencies: sodium orthovanadate was effective, metavanadate less active, and pyrovanadate without activity. Tetravalent vanadium, supplied as vanadyl sulfate or acetate, was utilized but produced smaller responses. The amounts of vanadium required are those normally found in tissues and nutrients.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>5112000</pmid><doi>10.1126/science.174.4007.426</doi><tpages>3</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0036-8075
ispartof	Science (American Association for the Advancement of Science), 1971-10, Vol.174 (4007), p.426-428
issn	0036-8075 1095-9203
language	eng
recordid	cdi_proquest_miscellaneous_81135659
source	American Association for the Advancement of Science; JSTOR Archival Journals and Primary Sources Collection
subjects	Amino acids Animals Body Weight Diet Dietary trace elements Growth - drug effects Nutritional Requirements Oxidation Rats Salts Sodium Sulfates Vanadates Vanadium Vanadium - administration & dosage Vanadium - pharmacology
title	Growth Effects of Vanadium in the Rat
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T23%3A14%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Growth%20Effects%20of%20Vanadium%20in%20the%20Rat&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Schwarz,%20Klaus&rft.date=1971-10-22&rft.volume=174&rft.issue=4007&rft.spage=426&rft.epage=428&rft.pages=426-428&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.174.4007.426&rft_dat=%3Cjstor_proqu%3E1731776%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c419t-73d046288a217dddb36e3bc1e784648f80687fcc561b251b8f5a190192db96093%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=81135659&rft_id=info:pmid/5112000&rft_jstor_id=1731776&rfr_iscdi=true