Leukaemia Virus-induced Alteration of Leucocyte Migration in vitro

INFECTION of susceptible mice by a leukaemia virus generally suppresses the immune response at both the cellular and humoral levels 1–8 . Although the mechanism of such immuno-depression is not fully understood, it is widely recognized that normal functions of the reticulo-endothelial system are aff...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1971-10, Vol.233 (5319), p.415-416
Main Authors: FRIEDMAN, HERMAN, CEGLOWSKI, WALTER S.
Format: Article
Language:English
Subjects:
Animals
Bone Marrow - immunology
Bone Marrow Cells
Cell Migration Inhibition
Humanities and Social Sciences
letter
Leukemia Virus, Murine
Leukocytes - immunology
Lymph Nodes - cytology
Lymph Nodes - immunology
Macrophages - immunology
Mice
multidisciplinary
Science
Science (multidisciplinary)
Spleen - cytology
Spleen - immunology
Thymus Gland - cytology
Thymus Gland - immunology
Virus Diseases - immunology
Virus Diseases - microbiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:INFECTION of susceptible mice by a leukaemia virus generally suppresses the immune response at both the cellular and humoral levels 1–8 . Although the mechanism of such immuno-depression is not fully understood, it is widely recognized that normal functions of the reticulo-endothelial system are affected by the leukaemic process. Earlier studies in this laboratory of the effects of leukaemia virus on cellular immunity included the macrophage migration inhibition assay with lymphoid cells from normal and virus infected mice sensitized to mycobacterial antigens 9 . It was found, however, that spleen cells from leukaemia virus-infected mice failed to migrate normally in vitro , even in the absence of antigen. Studies with normal mice showed that cells from lymphoid tissues other than the spleen, such as the thymus, bone marrow and superficial lymph nodes, as well as from the peripheral blood, migrated readily from capillary tube cultures 10 . The effects of leukaemia virus infection on the in vitro migration pattern of lymphoid cells from various organs were determined by comparison of infected and non-infected cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/233415a0