Electron Probe Analysis for Iodine in Human Thyroid and Parathyroid Glands, Normal and Neoplastic

Iodine analysis in human thyroid and parathyroid tissue, normal and neopiastic, was performed using the electron probe X-ray microanalyzer. Iodine within the limit of detection, >0.04%, was found in the follicular colloid of normal thyroid and thyroid adenomas, but not in cells lining the follicl...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1971-02, Vol.46 (2), p.269-273
Main Authors: Banfield, William G., Grimley, Philip M., Hammond, William G., Taylor, Charles M., deFlorio, Barbara, Tousimis, A. J.
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - metabolism
Adenoma - diagnosis
Adenoma - metabolism
Carcinoma - diagnosis
Carcinoma - metabolism
Diagnosis, Differential
Electron Probe Microanalysis
Histological Techniques
Humans
Iodine - analysis
Parathyroid Glands - analysis
Parathyroid Neoplasms - diagnosis
Parathyroid Neoplasms - metabolism
Thyroid Gland - analysis
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - metabolism
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Summary:Iodine analysis in human thyroid and parathyroid tissue, normal and neopiastic, was performed using the electron probe X-ray microanalyzer. Iodine within the limit of detection, >0.04%, was found in the follicular colloid of normal thyroid and thyroid adenomas, but not in cells lining the follicles. Paraffin embedding and hematoxylin and eosin staining did not diminish the detectability. With one exception, there was no iodine in the colloid-like material or cells of parathyroid glands. There was none in parathyroid adenomas, the colloid or cells of thyroid carcinomas, or the amyloid or cells of medullary carcinoma of the thyroid.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/46.2.269