Studies on metabolism of vitamin A. The effect of vitamin A status on the secretion rates of some steroids into the ovarian venous blood of pregnant rats

1. Rats raised on a vitamin A-deficient diet supplemented with either retinyl acetate or retinoic acid were mated and became pregnant. 2. The rates of secretion of progesterone, 20alpha-hydroxypregn-4-en-3-one, oestradiol-17beta and oestrone into the ovarian-venous blood of rats in these two groups...

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Bibliographic Details
Published in:Biochemical journal 1971-04, Vol.122 (2), p.235-239
Main Authors: Ganguly, J, Pope, G S, Thompson, S Y, Toothill, J, Edwards-Webb, J D, Waynforth, H B
Format: Article
Language:English
Subjects:
Animals
Carotenoids - metabolism
Diet
Estradiol - metabolism
Estrone - metabolism
Female
Gonadal Steroid Hormones - blood
Gonadal Steroid Hormones - metabolism
Hydroxysteroid Dehydrogenases - metabolism
Ovary - metabolism
Pregnancy
Pregnanes - metabolism
Progesterone - metabolism
Rats
Sterols - metabolism
Veins
Vitamin A Deficiency - metabolism
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Summary:1. Rats raised on a vitamin A-deficient diet supplemented with either retinyl acetate or retinoic acid were mated and became pregnant. 2. The rates of secretion of progesterone, 20alpha-hydroxypregn-4-en-3-one, oestradiol-17beta and oestrone into the ovarian-venous blood of rats in these two groups were measured on days 9 and 15 of pregnancy. 3. Rates of secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one, both on days 9 and 15, were lower for the rats given retinoic acid. No such differences were found in ovarian oestrogen secretion. 4. The implications of these results are discussed in the light of the previous demonstration that the activity of ovarian 3beta-hydroxy-Delta(5)-steroid dehydrogenase was markedly less in pregnant rats given retinoic acid.
ISSN:0264-6021
DOI:10.1042/bj1220235