Inner and outer complexes of Pt-coordination compounds with DNA probed by SERS spectroscopy

Surface enhanced Raman scattering (SERS) spectroscopy has been used to study the interfacial behaviour of DNA modified by cis-Pt(NH 3) 2Cl 2, ( cis-DDP) and [Pt-(dien)Cl]Cl bidentate and monodentate platinum coordination compounds, respectively. Two stereochemical configurations of Pt-DNA complexes...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 1984-07, Vol.173 (1), p.95-98
Main Authors: Séquaris, J.-M., Koglin, E., Malfoy, B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cisplatin - analogs & derivatives
DNA
DNA-Pt complex
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Interfacial behavior
Intermolecular phenomena
Molecular biophysics
Molecular Conformation
SERS spectroscopy
Spectrum Analysis, Raman
Stereochemical configuration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Surface enhanced Raman scattering (SERS) spectroscopy has been used to study the interfacial behaviour of DNA modified by cis-Pt(NH 3) 2Cl 2, ( cis-DDP) and [Pt-(dien)Cl]Cl bidentate and monodentate platinum coordination compounds, respectively. Two stereochemical configurations of Pt-DNA complexes can be deduced from the adsorption behaviour of the Pt adducts. The antitumoral inactive [Pt-(dien)Cl]Cl forms an outer complex whereas the antitumoral active cis-DDP favours an inner complex.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(84)81024-8