Adrenal Steroid Responses to ACTH in Glucocorticoid-Suppressible Aldosteronism

To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldos...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1984-07, Vol.6 (4), p.563-567
Main Authors: GANGULY, ARUNABHA, WEINBERGER, MYRON H, GUTHRIE, GORDON P, FINEBERG, NAOMI S
Format: Article
Language:English
Subjects:
18-Hydroxycorticosterone - blood
Adrenal Cortex Hormones - blood
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adrenocorticotropic Hormone - pharmacology
Aldosterone - blood
Biological and medical sciences
Corticosterone - blood
Endocrinopathies
Glucocorticoids - therapeutic use
Humans
Hydrocortisone - blood
Hyperaldosteronism - blood
Hyperaldosteronism - classification
Hyperaldosteronism - drug therapy
Hypertension - blood
Malignant tumors
Medical sciences
Stimulation, Chemical
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Summary:To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldosterone, cortisol, corticosterone, and 18-hydroxycorticosterone were measured. The results revealed a greater increase in the plasma aldosterone and 18- hydroxycorticosterone levels evoked by ACTH in the GSH group than in any other group, which suggested enhanced responsiveness of the aldosterone-producing cells to ACTH and a probable adrenal abnormality.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.6.4.563