Herpesvirus Type 2 Isolated from Cervical Tumor Cells Grown in Tissue Culture

A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic spe...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1971-11, Vol.174 (4010), p.704-707
Main Authors: Aurelian, Laure, Strandberg, John D., Melendez, Luis V., Johnson, Lorna A.
Format: Article
Language:English
Subjects:
Antigens, Viral - analysis
Carcinoma - microbiology
Carcinoma - pathology
Cell culture techniques
Cell nucleus
Cells, Cultured
Cellular immunity
Cultured cells
Female
Herpesviridae
Herpesviridae - immunology
Herpesviridae - isolation & purification
Human herpesvirus 1
Human herpesvirus 2
Humans
Microelectromechanical systems
Microscopy, Electron
Neutralization Tests
Ribosomes
Uterine Cervical Neoplasms - microbiology
Uterine Cervical Neoplasms - pathology
Virus Cultivation
Viruses
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Summary:A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic specificity as determined by neutralization. Herpesvirus antigens and virus particles were not seen in duplicate cultures of viable cervical tumor cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.174.4010.704