Effect of Zotepine on Fenfluramine-Induced Hyperthermia in Rats
Zotepine, 2-chloro-11-(2-dimethyl-aminoethoxy) dibenzo (b, f)thiepin, is a new neuroleptic structurally different from known neuroleptics. Fenfluramine is known to induce hyperthermia in rats by mediation of central serotonin in a warm environment (25-28 degree C). In the present study, rats with fe...
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Published in: | Japanese journal of pharmacology 1984, Vol.34(2), pp.261-263 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Zotepine, 2-chloro-11-(2-dimethyl-aminoethoxy) dibenzo (b, f)thiepin, is a new neuroleptic structurally different from known neuroleptics. Fenfluramine is known to induce hyperthermia in rats by mediation of central serotonin in a warm environment (25-28 degree C). In the present study, rats with fenfluramine-induced hyperthermia were used to investigate the anti-serotonergic activity of zotepine, and it was compared with clozapine, spiroperidol and oxypertine which are reported to have potent anti-serotonergic activity rather than anti-dopaminergic activity. |
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ISSN: | 0021-5198 1347-3506 |
DOI: | 10.1254/jjp.34.261 |