Effect of Zotepine on Fenfluramine-Induced Hyperthermia in Rats

Zotepine, 2-chloro-11-(2-dimethyl-aminoethoxy) dibenzo (b, f)thiepin, is a new neuroleptic structurally different from known neuroleptics. Fenfluramine is known to induce hyperthermia in rats by mediation of central serotonin in a warm environment (25-28 degree C). In the present study, rats with fe...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1984, Vol.34(2), pp.261-263
Main Authors: SATOH, Hisashi, FUJIWARA, Tatsujiro, MORI, Jo, SHIMOMURA, Kyoichi, ONO, Takaharu, KIKUCHI, Hiroyuki
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zotepine, 2-chloro-11-(2-dimethyl-aminoethoxy) dibenzo (b, f)thiepin, is a new neuroleptic structurally different from known neuroleptics. Fenfluramine is known to induce hyperthermia in rats by mediation of central serotonin in a warm environment (25-28 degree C). In the present study, rats with fenfluramine-induced hyperthermia were used to investigate the anti-serotonergic activity of zotepine, and it was compared with clozapine, spiroperidol and oxypertine which are reported to have potent anti-serotonergic activity rather than anti-dopaminergic activity.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.34.261