Relationships between genes on human chromosome 11 encoding cell-surface antigens

Genes encoding seven monoclonal antibody-defined cell-surface antigens have been regionally mapped on human chromosome 11, and compared to those of the AL complex defined by polyclonal antibodies using mutational analysis. MIC1, encoding W6/34 antigen, is probably identical to S1, previously mapped...

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Bibliographic Details
Published in:Somatic cell and molecular genetics 1984-07, Vol.10 (4), p.423-428
Main Authors: Jones, C, Bill, J, Larizza, L, Pym, B, Goodfellow, P, Tunnacliffe, A
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - immunology
Antigens, Surface - genetics
Chromosome Mapping
Chromosomes, Human, 6-12 and X
Genes
Glycolipids - genetics
Glycoproteins - genetics
Humans
Molecular Weight
Mutation
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Summary:Genes encoding seven monoclonal antibody-defined cell-surface antigens have been regionally mapped on human chromosome 11, and compared to those of the AL complex defined by polyclonal antibodies using mutational analysis. MIC1, encoding W6/34 antigen, is probably identical to S1, previously mapped to 11pter-p13. MDU1 and MIC8, encoding 4F2 and TRA-1.10 antigens, respectively, are probably identical to S2(a4) and map to 11q13-q22. MIC9, which governs expression of 4D12 and 2E2 antigens, and maps to 11q22-qter, is not related to any of the five AL genes. MIC4 and MIC11, both mapping to 11pter-p13, may have some relationship to S3 and S1, respectively, but identity has not been proven.
ISSN:0740-7750
1572-9931
DOI:10.1007/BF01535638