Immunization with Live Types 7 and 4 Adenovirus Vaccines. I. Safety, Infectivity, Antigenicity, and Potency of Adenovirus Type 7 Vaccine in Humans

Selective gastrointestinal infection without illness was induced in susceptible volunteers by oral administration of enteric-coated capsules containing live adenovirus type 7 (ADV-7). This vaccine was found similar to the live, oral adenovirus type 4 (ADV-4) vaccine in safety, infectivity, restricti...

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Bibliographic Details
Published in:The Journal of infectious diseases 1971-08, Vol.124 (2), p.148-154
Main Authors: Top, Franklin H., Grossman, Richard A., Bartelloni, Peter J., Segal, Herbert E., Dudding, Burton A., Russell, Philip K., Buescher, Edward L.
Format: Article
Language:English
Subjects:
Adenoviridae Infections - prevention & control
Adenoviruses
Adult
Antibodies
Capsules
Diseases
Humans
Immunization
Infections
Male
Methods
Military Medicine
Placebos
Respiratory Tract Infections - prevention & control
Vaccination
Viral Vaccines - administration & dosage
Viruses
Volunteerism
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Summary:Selective gastrointestinal infection without illness was induced in susceptible volunteers by oral administration of enteric-coated capsules containing live adenovirus type 7 (ADV-7). This vaccine was found similar to the live, oral adenovirus type 4 (ADV-4) vaccine in safety, infectivity, restriction of induced infection to the intestinal tract, and lack of transmission of vaccine virus from infected vaccinees to susceptible close contacts. Specific neutralizing antibody was stimulated in over 95% of infected volunteers by 21 days after immunization and levels of antibody were similar to levels of specific neutralizing antibody induced by the ADV-4 vaccine. Simultaneous administration of ADV-4 and ADV-7 vaccines was found to be safe and to stimulate neutralizing antibody to both viruses in 10 of 12 volunteers immunized. These studies suggest that live ADV-7 vaccine, given alone or with the ADV-4 vaccine, may be useful in the prevention of type-specific adenovirus disease in populations of military trainees.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/124.2.148