Immunization with Live Types 7 and 4 Adenovirus Vaccines. II. Antibody Response and Protective Effect against Acute Respiratory Disease Due to Adenovirus Type 7

• Published in: The Journal of infectious diseases 1971-08, Vol.124 (2), p.155-160
• Main Authors: Top, Franklin H., Buescher, Edward L., Bancroft, William H., Russell, Philip K.
• Format: Article
• Language: English
• Subjects: Adenoviridae - immunology; Adenoviridae Infections - prevention & control; Adenoviruses; Adult; Adult respiratory distress syndrome; Antibodies; Control groups; Humans; Immunization; Infections; Male; Methods; Military Medicine; Placebos; Respiratory diseases; Respiratory Tract Infections - prevention & control; Vaccination; Viral Vaccines - administration & dosage; Viruses
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/124.2.155

The antigenicity and protective effect of live, oral adenovirus type 7 (ADV-7) vaccine given simultaneously with the live, oral adenovirus type 4 (ADV-4) vaccine was evaluated in trainees at Fort Dix, New Jersey, during an outbreak of acute respiratory disease (ARD) due to ADV-7. The study was done in one cohort of six companies; by random selection, 20% of the men received both ADV-7 and ADV-4 vaccines (test group), and 80% received a placebo and ADV-4 vaccine (control group). No untoward reactions were noted. Eighty-six percent of trainees in the test group who lacked neutralizing (N) antibody to both types of adenoviruses developed N antibody to ADV-7 after immunization. No decrease in the antigenicity of the ADV-4 vaccine was evident when it was given with the ADV-7 vaccine. The rate of hospitalization due to ARD (47%) and the rate of ARD associated with ADV-7 (96%) were lower in the test group. This study confirmed the safety and antigenicity of ADV-7 vaccine when administered with ADV-4 vaccine and showed that the administration of the vaccines together protected against ARD associated with ADV-7.