Effects of carbamazepine and anti-depressant drugs on endogenous catecholamine levels in the cerebroventricular compartment of the rat

Concentrations of endogenous norepinephrine, dopamine and epinephrine in cerebroventricular perfusates were used to evaluate the effects of drugs on the availability of extracellular catecholamines in the intact rat brain. Administration of the antidepressant drugs imipramine, desmethylimipramine or...

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Bibliographic Details
Published in:Psychopharmacologia 1984-01, Vol.83 (2), p.169-171
Main Authors: KOWALIK, S, LEVITT, M, BARKAI, A. I
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Biological and medical sciences
Brain - metabolism
Carbamazepine - pharmacology
Catecholamines - analysis
Cerebral Ventricles - analysis
Dopamine - metabolism
Male
Medical sciences
Neuropharmacology
Perfusion
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
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Summary:Concentrations of endogenous norepinephrine, dopamine and epinephrine in cerebroventricular perfusates were used to evaluate the effects of drugs on the availability of extracellular catecholamines in the intact rat brain. Administration of the antidepressant drugs imipramine, desmethylimipramine or tranylcypromine resulted in marked increases of both norepinephrine and dopamine concentrations while epinephrine levels were not affected. Treatment with a similar dose of carbamazepine - an anticonvulsant drug with antidepressant activity - resulted in a significant increase in dopamine concentrations without apparent effect on either norepinephrine or epinephrine. It is suggested that at the applied dose, carbamazepine may act to modify the uptake, release or metabolism of dopamine in brain areas adjacent to the cerebroventricular space without affecting the other catecholamines.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00429729