Methysergide decreases prolactin release after FK 33-824 [Tyr-D-Ala-Gly-MePhe-Met(o)-ol], a potent analogue of methionine enkephalin. A study in man

This study investigated the mechanisms which may underly the prolactin (PRL) stimulating effects of FK 33-824, a potent enkephalin analogue. FK 33-824 (1 mg) was infused in healthy volunteers before and after pretreatment with 3 mg methysergide, a serotonin receptor blocker. All subjects showed a re...

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Bibliographic Details
Published in:Psychopharmacologia 1984-01, Vol.83 (2), p.210-212
Main Authors: JUNGKUNZ, G, NEDOPIL, N, RÜTHER, E
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
D-Ala,MePhe,Met-ol-enkephalin - pharmacology
Humans
Male
Medical sciences
Methysergide - pharmacology
Middle Aged
Miscellaneous
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Prolactin - metabolism
Receptors, Dopamine - drug effects
Receptors, Serotonin - drug effects
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Summary:This study investigated the mechanisms which may underly the prolactin (PRL) stimulating effects of FK 33-824, a potent enkephalin analogue. FK 33-824 (1 mg) was infused in healthy volunteers before and after pretreatment with 3 mg methysergide, a serotonin receptor blocker. All subjects showed a release of PRL after FK 33-824, which was significantly diminished after pretreatment with methysergide.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00429737