Immunohistology of normal and ovarian cancer tissue with a monoclonal antibody to placental alkaline phosphatase

A monoclonal antibody, designated NDOG2, has been shown to react with placental alkaline phosphatase. It does not bind to liver, kidney, bone, or intestinal alkaline phosphatase enzymes and has shown a positive reaction with all of over 50 placentae. Immunohistological studies have shown (a) a react...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1984-10, Vol.44 (10), p.4496-4502
Main Authors: SUNDERLAND, C. A, DAVIES, J. O, STIRRAT, G. M
Format: Article
Language:English
Subjects:
Adult
Alkaline Phosphatase - analysis
Antibodies, Monoclonal
Antigen-Antibody Complex
Biological and medical sciences
Cross Reactions
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Histocytochemistry
Humans
Isoenzymes - analysis
Medical sciences
Ovarian Neoplasms - enzymology
Ovarian Neoplasms - pathology
Ovary - cytology
Ovary - enzymology
Placenta - enzymology
Tumors
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Summary:A monoclonal antibody, designated NDOG2, has been shown to react with placental alkaline phosphatase. It does not bind to liver, kidney, bone, or intestinal alkaline phosphatase enzymes and has shown a positive reaction with all of over 50 placentae. Immunohistological studies have shown (a) a reaction with respiratory bronchiolar epithelium of lung, endocervical gland epithelium, the epithelium of fallopian tube, and certain reticular cells in the thymic medulla; (b) no detectable staining with ten other normal tissues including testis and tonsil; and (c) a significant reaction with nine of 13 ovarian cystadenocarcinomas and little or no staining with four malignant ovarian tumors of other histopathological types. The NDOG2 antibody may be of value as a marker in patients with ovarian cystadenocarcinoma.
ISSN:0008-5472
1538-7445