Uric acid metabolism in two patients with coexistent Down's syndrome and gout

Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathwa...

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Bibliographic Details
Published in:Clinical rheumatology 1984-06, Vol.3 (2), p.229-233
Main Authors: Ciompi, M L, Bazzichi, L M, Bertolucci, D, Mazzoni, M R, Barbieri, P, Mencacci, S, Macchia, D, Mariani, G
Format: Article
Language:English
Subjects:
Adult
Down Syndrome - blood
Down Syndrome - complications
Glomerular Filtration Rate
Gout - blood
Gout - complications
Humans
Male
Uric Acid - blood
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Summary:Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathway were found, and the turnover parameters of uric acid, determined by means of a 14C-labeled uric acid study, were consistent with the metabolic findings observed in normoexcretor gouty patients.
ISSN:0770-3198
1434-9949
DOI:10.1007/BF02030760