Antibody to Transcobalamin II and B12 Binding Capacity in Patients Treated With Hydroxocobalamin

Thirty-two patients treated for B12 deficiency with one or two initial depot series of five i.m. injections of 1 mg hydroxocobalamin on alternate days followed by i.m. injection of 1 mg hydroxocobalamin every third month for maintenance therapy were examined after more than 2 yr of treatment. Antibo...

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Bibliographic Details
Published in:Blood 1971-12, Vol.38 (6), p.769-774
Main Authors: Skouby, Arne P., Hippe, Erik, Olesex, Henrik
Format: Article
Language:English
Subjects:
Anemia, Macrocytic - immunology
Anemia, Pernicious - immunology
Antibodies - analysis
Antibody Formation
Cobalt Isotopes
Electrophoresis
Gels
Humans
Immunoelectrophoresis
Vitamin B 12 - therapeutic use
Vitamin B 12 Deficiency - drug therapy
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Summary:Thirty-two patients treated for B12 deficiency with one or two initial depot series of five i.m. injections of 1 mg hydroxocobalamin on alternate days followed by i.m. injection of 1 mg hydroxocobalamin every third month for maintenance therapy were examined after more than 2 yr of treatment. Antibody to TC II demonstrable after agar gel electrophoresis was detected in 5 of 12 patients given two depot series 1–3 mo apart, while antibody to TC II detectable only after the more sensitive immunoelectrophoresis occurred in 2 of 20 patients given one initial depot series or two series 6 or 12 mo apart. No anti-TC II was observed in serum from untreated patients with pernicious anemia.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V38.6.769.769