Quantitation of human synovial mast cells in rheumatoid arthritis and other rheumatic diseases

We examined sections of synovial membranes from 14 patients with rheumatoid arthritis (RA), 7 with other rheumatic diseases, and 10 with no apparent joint disease. Patients with RA and other rheumatic diseases had significantly more synovial mast cells/vessel than patients with no joint disease (0.4...

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Bibliographic Details
Published in:Arthritis and rheumatism 1984-08, Vol.27 (8), p.852-856
Main Authors: Godfrey, Henry P., Ilardi, Carl, Engber, William, Graziano, Frank M.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - pathology
Biological and medical sciences
Cell Count
Diseases of the osteoarticular system
Histological Techniques
Humans
Immunoglobulin E - analysis
Inflammatory joint diseases
Mast Cells - cytology
Medical sciences
Rheumatoid Factor - analysis
Synovial Membrane - cytology
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Summary:We examined sections of synovial membranes from 14 patients with rheumatoid arthritis (RA), 7 with other rheumatic diseases, and 10 with no apparent joint disease. Patients with RA and other rheumatic diseases had significantly more synovial mast cells/vessel than patients with no joint disease (0.49 and 0.20, respectively, versus 0.03). They also had significantly more total mast cells/10 fields than patients with no joint disease (9.9 and 5.0, respectively, versus 0.4). Within the rheumatoid group, patients with active disease had more total mast cells/10 fields than patients clinically considered to have end‐stage disease (P < 0.05). Synovial basophils were not identified in any patient. Synovial vascularity was similar for all groups (2.3 vessels/field). The role of the synovial mast cell in RA and other rheumatic diseases remains to be determined.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780270803