Vaccine-associated poliomyelitis in a child with thymic abnormality

An 8-month-old girld develoepd paralytic poliomyelitis. Twenty-nine days prior to the onset of paralysis she had been in contact with a sibling recently immunized with trivalent oral polio vaccine. The patient died because of intercurrent respiratory infection. "Vaccine-like" Type 3 poliov...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1971-12, Vol.48 (6), p.923-929
Main Authors: Riker, J B, Brandt, C D, Chandra, R, Arrobio, J O, Nakano, J H
Format: Article
Language:English
Subjects:
Agammaglobulinemia - complications
Autopsy
Central Nervous System - pathology
Congenital Abnormalities - pathology
Female
Humans
Infant
Infant, Newborn
Lymphoid Tissue - pathology
Paralysis - complications
Paralysis - etiology
Paralysis - pathology
Poliomyelitis - complications
Poliomyelitis - etiology
Poliomyelitis - pathology
Poliovirus - isolation & purification
Poliovirus Vaccine, Oral - adverse effects
Thymus Gland - abnormalities
Thymus Gland - pathology
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Summary:An 8-month-old girld develoepd paralytic poliomyelitis. Twenty-nine days prior to the onset of paralysis she had been in contact with a sibling recently immunized with trivalent oral polio vaccine. The patient died because of intercurrent respiratory infection. "Vaccine-like" Type 3 poliovirus was isolated from the throat, stool, and postmortem brain and spinal cord spciemens. Histologic examination revealed depltion of all lymphoid tissues. Serum immunoglobulin levels were adequate. We believe this child presents a variant of the syndrome of hereditary thymic dysplasia.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.48.6.923